Results 111 to 120 of about 269,198 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Simulation of marker-assisted recurrent selection in autogamous species

Crop Breeding and Applied Biotechnology, 2002
This work used computer simulation to evaluate marker-assisted selection (MAS) in recurrent selection of autogamous species. Base populations were simulated by crossing each of five inbred lines with two others.
Eduardo Bearzoti, Roland Vencovsky
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Evaluation of sorghum grain quality for QTL analysis and Marker Assisted Recurrent Selection (MARS) : [P1121] [PDF]

, 2014
Sorghum breeding in Mali mostly focuses on varieties for human consumption. Even if most of breeding efforts concentrate on productivity and adaptation, grain quality is a very important aspect to consider for improved material to be adopted and ...
Davrieux, Fabrice, Fliedel, Geneviève, Guindo, Diarah, Guitton, Baptiste, Kapitan Gnimdu, André, Rami, Jean-François, Teme, Niaba, Vaksmann, Michel   +7 more
core  

Using marker-maps in marker-assisted selection

Genetical Research, 1995
SummaryA method of using information on the location of markers to improve the efficiency of markerassisted selection (MAS) in a population produced by a cross between two inbred lines is developed. The method is closer to mapping QTL than the selection index approaches to MAS described by previous authors.
J C, Whittaker, R N, Curnow, C S, Haley, R, Thompson   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Phenotypic evaluation of the CIRAD cotton germplasm collection [PDF]

, 2008
The CIRAD cotton germplasm collection was founded in 1978 and currently includes 3,070 accessions, of which 2,724 have been described for botanical, agronomic and technological traits.
Dessauw, Dominique, Hau, Bernard
core  

Marker‐assisted selection in cattle

Animal Biotechnology, 1992
Abstract Direct observation of genetic differences using molecular techniques has prompted investigation into the nature and amount of genetic variation in cattle. Utilization of molecular data will include parentage analysis, individual identification, sexing of embryos and clones and detection of genetic defects.
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Knowledge database assisted gene marker selection for chronic lymphocytic leukemia

Journal of International Medical Research, 2018
Objective To investigate whether previously curated chronic lymphocytic leukemia (CLL) risk genes could be leveraged in gene marker selection for the diagnosis and prediction of CLL.
Xixi Xiang, Yu-Ping Wang, Hongbao Cao, Xi Zhang   +3 more
doaj   +1 more source