Results 111 to 120 of about 42,796 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simulation of marker-assisted recurrent selection in autogamous species

Crop Breeding and Applied Biotechnology, 2002
This work used computer simulation to evaluate marker-assisted selection (MAS) in recurrent selection of autogamous species. Base populations were simulated by crossing each of five inbred lines with two others.
Eduardo Bearzoti, Roland Vencovsky
doaj  

Validation of KASP Markers Associated with Hydrogen Cyanide in Fresh Cassava Roots in Uganda Cassava Germplasm

Agronomy
Low hydrogen cyanide (HCN) concentration is a high-priority trait for cassava varieties targeting their fresh and dry product profiles. To be acceptable, varieties bred and developed for these market segments must meet international safety standards for ...
Michael Kanaabi, Settumba B. Mukasa, Ephraim Nuwamanya, Paula Iragaba, Julius Karubanga Baguma, Ann Ritah Nanyonjo, Henry Wagaba, Nicholas Muhumuza, Fatumah Babirye Namakula, Enoch Wembabazi, Alfred Ozimati, Ismail Siraj Kayondo, Williams Esuma, Robert S. Kawuki   +13 more
doaj   +1 more source

Genomic Selection Accuracy using Multifamily Prediction Models in a Wheat Breeding Program

The Plant Genome, 2011
Genomic selection (GS) uses genome-wide molecular marker data to predict the genetic value of selection candidates in breeding programs. In plant breeding, the ability to produce large numbers of progeny per cross allows GS to be conducted within each ...
Elliot L. Heffner, Jean-Luc Jannink, Mark E. Sorrells   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

High throughput phenotyping methods for screening rice germplasm under water limited field conditions [PDF]

, 2010
A Cirad project (Orytage) involving NARS and IRC aims at developing an international phenotyping network for rice adaptations to drought and thermal stresses in the context of gene discovery and genetic mapping.
Audebert, Alain, Châtel, Marc, Grenier, Cécile, Ospina, Yolima, Rodriguez, Francisco   +4 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic analysis identifies key loci for traits and resistance in Qinghai plateau wheat F2 populations

Scientific Reports
The Qinghai Plateau’s high-altitude conditions present significant challenges for wheat cultivation, demanding varieties with enhanced adaptability and stress resistance.
Demei Liu, Ahmed H. El-Sappah, Ahmed S. Eldomiaty, Haiqing Wang, Wenjie Chen, Ruijuan Liu, Jicheng Shen, Fahui Ye   +7 more
doaj   +1 more source

Use of DNA-based genetic markers in plant breeding [PDF]

, 2005
Genetic markers have been used since the beginnings of plant breeding, but the concept of linkage and recently the availability of molecular markers have offered new and powerful tools that can help to perform the traditional tasks of selection or that ...
Backes, Gunter
core