Results 131 to 140 of about 42,796 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

SNAP markers for pyramided yield and BLB resistance genes in rice

Crop Breeding and Applied Biotechnology
Molecular markers are pivotal in rice breeding as they enable gene pyramiding to improve yield and disease resistance. This study reports the development and validation of Single Nucleotide Amplified Polymorphism (SNAP) markers targeting qTSN4 (yield ...
Andhika Faisal Mubarok, Sigit Purwantomo, Antonius Suwanto, Reflinur Reflinur, Sintho Wahyuning Ardie   +4 more
doaj  

Molecular markers in maize breeding [PDF]

Selekcija i Semenarstvo, 2011
Today the marker assisted selection (MAS) is being routinely applied in breeding programs of large private companies. However, the implementation of molecular markers for commercial use in small companies and public sec- tor is on a considerably smaller ...
Treskić Sanja, Ivanović Mile, Kobiljski Borislav, Kondić-Špika Ankica, Brbaklić Ljiljana, Trkulja Dragana, Stanisavljević Dušan, Mitrović Bojan   +7 more
doaj  

The use of general and specific combining abilities in a context of gene expression relevant to plant breeding [PDF]

Many common traits are believed to be a composite reflection of multiple genetic and environmental factors. Recent advances suggest that subtle variations in the regulation of gene expression may contribute to quantitative traits.
Eeuwijk, F.A., van, Vuylsteke, M.
core   +2 more sources

Marker-assisted-selection (MAS): A fast track to increase genetic gain in horticultural crop breeding

African Journal of Biotechnology, 2013
Mapping and tagging of agriculturally important genes have been greatly facilitated by an array of molecular markers in crop plants. Marker-assisted selection (MAS) is gaining considerable importance as it would improve the efficiency of plant breeding through precise transfer of genomic regions of interest (foreground selection) and accelerate the ...
Ibitoye, DO, Akin-Idowu, PE
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Association of candidate genes for fatty acid content in soybean by temperature-switch PCR (TSP) genotyping

Crop Breeding and Applied Biotechnology, 2018
The development of molecular markers is essential for improvement of soybean cultivars with modified fatty acid content. The objective of this study was to identify and validate SNP markers in candidate genes for fatty acid content in soybean.
Rafael Delmond Bueno, Pedro Ivo Vieira Good God, Isadora Oliveira Prata, Pedro Henrique Scarpelli Pereira, Arlindo Inês Teixeira, Newton Deniz Piovesan, Everaldo Gonçalves de Barros   +6 more
doaj  

Location of a chromosome region linked to Alternaria Brown Spot resistance from the evaluation of triploid mandarin populations [PDF]

, 2015
Alternaria brown spot (ABS) in citrus is a serious disease caused by the tangerine pathotype of the fungus Alternaria alternate, which induces necrotic lesions on fruit and young leaves, defoliation and fruit drop in susceptible genotypes. It is a strong
Aleza, Pablo, Cuenca, José, Iborra, Enrique, Navarro, Luis, Ollitrault, Patrick, Vicent, Antonio   +5 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source