Aberrant Cluster of Differentiation (CD) Marker Expression Across B-cell Chronic Lymphoproliferative Disorder Subtypes: A Single-Center Flow Cytometry Study From Sri Lanka. [PDF]
CureusBalasuriya T +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Expanding the Zooarchaeology by Mass Spectrometry reference library for North American mammals: new collagen fingerprints from extinct and extant taxa. [PDF]
R Soc Open SciAntonosyan M +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The High-Amylose Maize Line GEMS-0067 Is Associated with an Intron 8 Insertion in <i>Sbe1a</i>, Altered Native PAGE Zymogram Patterns, and Development of PCR Markers for Breeding Applications. [PDF]
Plants (Basel)Campbell MR, Karn A, Scott MP, Farno LA.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A Simplified and Solvent-Reduced HPLC-UV/Vis Method for the Simultaneous Determination of Major Marker Compounds in <i>Rhodiola rosea</i> L. [PDF]
MoleculesStabl A +5 more
europepmc +1 more source