Results 91 to 100 of about 4,756,439 (283)

Efficiency of bovine IGF-i gene in the improvement of milk productivity using marker-assisted selection (MAS)

Biotechnology in Animal Husbandry, 2011
Because of insulin-like growth factor-I (IGF-I) gene plays an important regulatory function in milk secretion in cattle, IGF1 gene is potential quantitative trait locus and genetic marker (i.e, SNP) associated with milk production trait in cattle.
S.M. Abdel-Rahman, S.A. Hemeda, M.M. Fouda, A.I. Ateya   +3 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Workshop on marker-trait analyses and marker-assisted selection strategies

, 2017
Workshop on marker-trait analyses and marker-assisted selection ...
Aubert, Gregoire, Nazzicari, Nelson, Annicchiarico, Paolo, Julier, Bernadette   +3 more
core   +4 more sources

Marker-assisted selection for cyclaneusma minus in pinus radiata

, 2002
Marker-assisted selection for cyclaneusma minus in pinus ...
Tamsyn Crowley (13097181), Morley Muralitharan (13085757), J Simpson (8412294), T Stevenson (7642736)   +3 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Evaluating Selection of a Quantitative Trait: Snow Mold Tolerance in Winter Wheat

Agrosystems, Geosciences & Environment, 2019
Core Ideas Six quantitative trait loci for snow mold tolerance were detected in a winter wheat recombinant inbred line population. Marker‐assisted selection to incorporate QTL is unlikely to help breed for highly quantitative traits.
Erika B. Kruse, Kathy L. Esvelt Klos, Juliet M. Marshall, Timothy D. Murray, Brian P. Ward, Arron H. Carter   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Detection of QTLs for important agronomical traits in hexaploid wheat using association analysis

Czech Journal of Genetics and Plant Breeding, 2013
One of the main wheat breeder's goals is determining specific genomic regions which control important agronomical traits. Association analysis is a new strategy with high resolution in plant molecular breeding that could be used to improve the efficiency
Ljiljana BRBAKLIC, Dragana TRKULJA, Ankica KONDIC-SPIKA, Sanja TRESKIC, Borislav KOBILJSKI   +4 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Validation of KASP Markers Associated with Hydrogen Cyanide in Fresh Cassava Roots in Uganda Cassava Germplasm

Agronomy
Low hydrogen cyanide (HCN) concentration is a high-priority trait for cassava varieties targeting their fresh and dry product profiles. To be acceptable, varieties bred and developed for these market segments must meet international safety standards for ...
Michael Kanaabi, Settumba B. Mukasa, Ephraim Nuwamanya, Paula Iragaba, Julius Karubanga Baguma, Ann Ritah Nanyonjo, Henry Wagaba, Nicholas Muhumuza, Fatumah Babirye Namakula, Enoch Wembabazi, Alfred Ozimati, Ismail Siraj Kayondo, Williams Esuma, Robert S. Kawuki   +13 more
doaj   +1 more source