Development of somatic markers guiding decision-making along adolescence
Serra Sandor, Hakan Gürvit
openaire +4 more sources
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Deep neural network-based biostatistical analysis for disease marker screening. [PDF]
Wang X.
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Selective Drug-Free Active Surveillance in Ulcerative Colitis: Biomarker-Guided, Patient-Centered Approach. [PDF]
Nishida T +3 more
europepmc +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
PLK1 as A Potential Prognostic Marker of Gastric Cancer Through MEK-ERK Pathway on PDTX Models [Retraction]. [PDF]
europepmc +1 more source
Adaptive Multi-Camera Fusion and Calibration for Large-Scale Multi-Vehicle Cooperative Simulation Scenarios. [PDF]
Zhang H, Xia C, Zeng H.
europepmc +1 more source
Parallel universes and parallel measures: estimating the reliability of test results [PDF]
Benton, Tom, Hutchison, Dougal
core

