Results 171 to 180 of about 2,729,076 (335)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Efficacy of marker vaccine candidate CP7_E2alf in piglets with maternally derived C-strain antibodies.

Vaccine, 2012
D. Rangelova, J. Nielsen, B. Strandbygaard, F. Koenen, S. Blome, A. Uttenthal   +5 more
semanticscholar   +1 more source

Risk Factors for Small‐for‐Size Syndrome Grade B/C After Simultaneous Splenectomy in Adult Living‐Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
In a single‐center cohort of 577 adult LDLT recipients who underwent simultaneous splenectomy, clinically significant SFSS grade B/C (ILTS‐iLDLT‐LTSI 2023) occurred in 18.2% and was associated with inferior graft survival. Multivariate analysis identified MELD ≥ 30, NLR ≥ 4.5, and donor age ≥ 50 years as independent risk factors, which risk rising ...
Kyohei Yugawa, Takeo Toshima, Shinji Itoh, Takashi Motomura, Shohei Yoshiya, Norifumi Iseda, Tomoharu Yoshizumi   +6 more
wiley   +1 more source

Antigen-specific Th1 cytokine markers and protection against tuberculosis: a systematic review and meta-analysis stratified by progression to active disease and sustained IGRA conversion. [PDF]

Front Cell Infect Microbiol
Lin T, Liu S, Pan YY.
europepmc   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Development of a unified mass cytometry assay integrating activation-induced markers (AIMs) and cytokine profiling for high-throughput assessment of antigen-specific T cell responses. [PDF]

Hum Vaccin Immunother
Wan N, Xue Y, Chen S, Yu H, Ma X, Cheng R, Jiang X, Zhang ZS, Yang W, Li J, Chen Y.   +10 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Assessment of the long-term effect of vaccination on transmission of infectious bovine rhinotracheitis virus in cattle herds hyperimmunized with glycoprotein E-deleted marker vaccine.

American Journal of Veterinary Research, 2012
B. Ampe, L. Duchateau, N. Speybroeck, D. Berkvens, A. Dupont, P. Kerkhofs, E. Thiry, M. Dispas   +7 more
semanticscholar   +1 more source

Automated Discovery of Multicellular Behavior for Optimized Plant Growth and Climate Resilience

Advanced Intelligent Systems, EarlyView.
An automated robotic system is described for rapid scientific experimentation with multicellular organisms. By enhancing a robotic liquid handler with a custom developed deep learning algorithm and camera module, samples and data are prepared with minimal human intervention.
Mark A. DeAngelis, Philip R. LeDuc, Warren C. Ruder   +2 more
wiley   +1 more source

Immune Correlates and Vaccine Immunobridging: Statistical Innovations, Challenges, and Opportunities. [PDF]

J Infect Dis
Carone M, Wolock CJ, Olivas-Martinez A, Rotnitzky A, Gilbert PB.   +4 more
europepmc   +1 more source