Results 201 to 210 of about 2,729,076 (335)

Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application.

Veterinary Research, 2006
C. Frey, O. Bauhofer, N. Ruggli, A. Summerfield, M. Hofmann, J. Tratschin   +5 more
semanticscholar   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

The construction of recombinant DNA vaccine pVAX-ROP27-IL-2-IFN-γ and its immune enhancement effect against Eimeria tenella. [PDF]

Poult Sci
Niu Z, Zhao J, Dou K, Liu K, Xu M, Li MG, Cui X, Bai R, Zheng M, Lv X.   +9 more
europepmc   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

A Phase II Trial to Evaluate the Safety and Immunogenicity of Two Doses of a Folate Receptor Alpha Vaccine in Patients with Triple-Negative Breast Cancer. [PDF]

Clin Cancer Res
Knutson KL, Abu-Fares H, Keating P, Block MS, Norton N, Erskine CL, Cogen D, Assad H, Graff SL, Hamilton EP, Han HS, McIntyre KJ, Nassar A, Sparano JA, Tiersten A, Tkaczuk KH, Ward PJ, Wilson G, Garrett G, Kenney RT, Sharma P.   +20 more
europepmc   +1 more source

Information behavior patterns and subjective digital well‐being: An exploratory study on perceptions of adults living in Germany

Journal of the Association for Information Science and Technology, EarlyView.
Abstract This exploratory study examines patterns of digital information behaviors such as information seeking, use, sharing, evaluation, avoidance, and curation to determine how they relate to subjective digital well‐being. To explore adults' personal views on their digital well‐being, conceptualized here as subjective digital well‐being, this study ...
Leyla Dewitz
wiley   +1 more source

Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV. [PDF]

Nat Commun
Mkhize NN, Zhang B, Brackett C, Elyanu PJ, Tapley A, Dadabhai S, Hu J, Do BTN, Schuster DJ, Heptinstall J, Sawant S, Seaton K, Sarzotti-Kelsoe M, Hudson A, Jin Y, Bhebhe S, Kaldine H, Kgagudi P, Modise T, Mgodi NM, Andriesen J, Randhawa AK, Fisher LH, Kee JJ, Magaret CA, Peng J, Kenny A, Carpp LN, Chen Z, Heng S, Villaran M, Takalani A, Le Roux B, Wilkinson E, Odhiambo J, Shah P, Polakowski L, Yacovone M, Samandari T, Chirenje Z, Makhema J, Kamuti E, Njekwa K, Nuwagaba-Biribonwoha H, Baguma A, Badal-Faesen S, Brumskine W, Coetzer S, Dawson R, Delany-Moretlwe S, Diacon AH, Fry S, Gill K, Madikida A, Hoosain ZAE, Hosseinipour MC, Inambao M, Innes C, Innes S, Kalonji D, Mwape H, Kassim P, Kamanga MC, Kilembe W, Laher F, Malahleha M, Maluleke VL, Mboya G, Madiega PA, McHarry K, Mitha E, Duki Y, Mda P, Moerane M, Moloantoa T, Nuwamanya S, Mahomed S, Naicker V, Nana A, Nanvubya A, Kawoozo B, Nchabeleng M, Otieno W, Potgieter EL, Potloane D, Punt Z, Said J, Singh Y, Kassim S, van der Vendt D, Tayob MS, Vahed Y, Wabwire DO, Kublin JG, Bekker LG, Corey L, Gray GE, Huang Y, Kotze P, Garrett N, Hural J, Ferrari G, Andersen-Nissen E, Montefiori D, Moore PL, McElrath MJ, Tomaras GD, Gilbert PB, CoVPN 3008 Study Team.   +108 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Analysis of antibody markers as immune correlates of risk of severe COVID-19 in the PREVENT-19 efficacy trial of the NVX-CoV2373 recombinant protein vaccine. [PDF]

Clin Infect Dis
Fong Y, Huang Y, Huang Y, Woo W, McGarry A, Áñez G, Dunkle LM, Cho I, Houchens CR, Martins K, Jayashankar L, Castellino F, Petropoulos CJ, Leith A, Haugaard D, Webb W, Lu Y, Yu C, Carpp LN, Randhawa AK, Andrasik MP, Kublin JG, Hutter J, Keshtkar-Jahromi M, Beresnev TH, Rodriguez CA, Tapia M, Turley CB, Zorrilla CD, Cohen SH, Kline SE, Barranco E, Corey L, Neuzil KM, Follmann D, Ake JA, Gay CL, Kotloff KL, Jones T, Koup RA, Donis RO, Gilbert PB.   +41 more
europepmc   +1 more source