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Vaccine, 2019
Here, we constructed an attenuated live marker classical swine fever (CSF) vaccine (Flc-LOM-BErns) to eradicate CSF. This was done by taking infectious clone Flc-LOM, which is based on an attenuated live CSF vaccine virus (LOM strain), and removing the ...
Seong-In Lim +12 more
semanticscholar +1 more source
Here, we constructed an attenuated live marker classical swine fever (CSF) vaccine (Flc-LOM-BErns) to eradicate CSF. This was done by taking infectious clone Flc-LOM, which is based on an attenuated live CSF vaccine virus (LOM strain), and removing the ...
Seong-In Lim +12 more
semanticscholar +1 more source
1978
Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
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Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
openaire +2 more sources
Laboratory markers for over-attenuation of mumps vaccine virus
Vaccine, 1988The properties of mumps vaccine virus (Leningrad-3 strain) gradually changed upon passaging in quail embryo fibroblasts, the substrate normally used for mumps vaccine production in the USSR. Alterations were extremely noticeable in the over-attenuated (38th passage) virus variant, and involved (a) poor, if any, antibody response in guinea-pigs, (b ...
, Boriskin YuS +4 more
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Vaccine, 1997
A comparative study was carried out to evaluate the efficacy of three bovine herpesvirus 1 (BHV1) marker vaccines to reduce the reexcretion of virus after reactivation of latent BHV1. A live gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested in three identical experiments in which cattle, latently
Bosch, J.C. +2 more
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A comparative study was carried out to evaluate the efficacy of three bovine herpesvirus 1 (BHV1) marker vaccines to reduce the reexcretion of virus after reactivation of latent BHV1. A live gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested in three identical experiments in which cattle, latently
Bosch, J.C. +2 more
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Experiences with two BHV1 marker vaccines
The Bovine Practitioner, 1997Both marker vaccines tested were deleted vaccines, one had a gG, the other a gE deletion. The gG deleted vaccine was inactivated the gE deleted vaccine had a live and an inactivated form. The object of the trial was to evaluate these vaccines in heifers and calves. Twenty young heifers were used for the inactivated deleted vaccines and 16 four week old
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Veterinary Microbiology, 2002
Control/eradication plans of bovine herpesvirus 1 (BHV1) and suid herpesvirus 1 (SHV1) infections involve vaccination with inactivated or attenuated gE-deleted marker vaccines and associated companion serological tests to discriminate naturally infected from vaccinated animals.
D, Lehmann +3 more
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Control/eradication plans of bovine herpesvirus 1 (BHV1) and suid herpesvirus 1 (SHV1) infections involve vaccination with inactivated or attenuated gE-deleted marker vaccines and associated companion serological tests to discriminate naturally infected from vaccinated animals.
D, Lehmann +3 more
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Overview of marker vaccine and differential diagnostic test technology
Biologicals, 2005Recent advances in molecular biology, immunology, microbiology, genetics and microbial pathogenesis have lead to the development of a wide variety of new approaches for developing safer and more effective vaccines based on designs such as subunit vaccines, gene deleted vaccines, live vectored vaccines, and DNA mediated vaccines. Technology tools can be
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Vaccine, 2005
Some important vaccines, including ones against tuberculosis (Tb) and foot-and-mouth disease (FMD), are not used in many developed countries because there is no simple way to differentiate between vaccine-induced immunity and infection. Eliminating major protein antigens has not succeeded in the cases of Tb, FMD and some other vaccine preparations ...
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Some important vaccines, including ones against tuberculosis (Tb) and foot-and-mouth disease (FMD), are not used in many developed countries because there is no simple way to differentiate between vaccine-induced immunity and infection. Eliminating major protein antigens has not succeeded in the cases of Tb, FMD and some other vaccine preparations ...
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Markers of Cell-Mediated Immunity After Vaccination with an Inactivated, Whole-Cell Q Fever Vaccine
Journal of Infectious Diseases, 1988A clinical trial of Q fever vaccine in four South Australian abattoirs showed apparently complete protection against natural infection; however, only 50%-60% of vaccinees developed complement-fixing or immunofluorescent antibody after vaccination. Cell-mediated immunity to Coxiella burnetii antigens, as measured by an index of lymphoproliferative ...
A A, Izzo, B P, Marmion, D A, Worswick
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Vaccine, 1997
The efficacy of two experimental subunit gD vaccines and two commercial whole virus vaccines was determined in a bovine herpesvirus-1 (BHV1) challenge trial. Full-length gD and a truncated, secreted form of gD (tgD) were produced using a vaccinia virus expression system and purified by affinity chromatography.
S, van Drunen Littel-van den Hurk +4 more
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The efficacy of two experimental subunit gD vaccines and two commercial whole virus vaccines was determined in a bovine herpesvirus-1 (BHV1) challenge trial. Full-length gD and a truncated, secreted form of gD (tgD) were produced using a vaccinia virus expression system and purified by affinity chromatography.
S, van Drunen Littel-van den Hurk +4 more
openaire +2 more sources