Results 101 to 110 of about 246,238 (279)

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Emerging Adulthood Measured at Multiple Institutions 2: The Data

Journal of Open Psychology Data, 2018
Collaborators from 32 academic institutions primarily in the United States collected data from emerging adults (N'raw''' = 4220, N'processed' = 3134).
Jon E. Grahe, Holly M. Chalk, Leslie D. Cramblet Alvarez, Caitlin S. Faas, Anthony D. Hermann, Joseph P. McFall   +5 more
doaj   +1 more source

The role of childhood social position in adult type 2 diabetes: Evidence from the English Longitudinal Study of Ageing [PDF]

, 2014
Copyright @ 2014 Pikhartova et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any ...
A Case, AJ Pyykkonen, B Galobardes, B Kowall, BH Strand, BJ Lehman, BT Smith, DA Lawlor, DA Lawlor, David Blane, DM Rabi, E Agardh, E Agardh, EE Agardh, ELM Gonzales, FB Hu, FL Game, G Mishra, Gopalakrishnan Netuveli, H Yki-Järvinen, I Perry, IV Kohler, J Lidfeldt, JC Pickup, JG Eriksson, Jitka Pikhartova, JM Robbins, JW Lynch, LE Best, M Marmot, M Wei, NA Ross, P Demakakos, P Demakakos, PM McKeigue, SA Everson, SC Maty, SP Helmrich, T Sairenchi, W Rathmann   +39 more
core   +1 more source

Linking sense of purpose and multiple markers of health in older adulthood: A bidirectional approach

European Journal of Personality
Sense of purpose is a key construct explaining individual differences in health. However, much is still unclear about how sense of purpose and health affect each other over time in older age. Using four waves of data from the Health and Retirement Study ( N = 11,390, 50+ years old) spanning 12 years, we investigated
Flavia S. Chereches, Gudrun R. Gudmundsdottir, Gabriel Olaru   +2 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain [PDF]

, 2015
peer-reviewedBackground Excessive maternal weight gain during pregnancy impacts on offspring health. This study focused on the timing of maternal gestational weight gain, using a porcine model with mothers of normal pre-pregnancy weight.
Berry, Donagh, Blancher, Florence, Castaneda-Gutierrez, Euridice, Darimont, Christian, Giblin, Linda, Lawlor, Peadar G, Leone, Patricia, McNamara, Louise B.   +7 more
core   +1 more source

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]

, 2020
Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi, Breton, Edith, Cardenas, Andres, Fortin, Carol-Ann, Gagné-Ouellet, Valérie, Guérin, Renée, Hivert, Marie-France, Perron, Patrice, Thibeault, Kathrine   +8 more
core   +1 more source

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study [PDF]

, 2020
AbstractBackgroundThe potential benefits of gaining body muscle mass and strength for atherogenic trait levels in young adulthood, and how these compare with the potential harms of gaining body fat, are unknown.MethodsData were from first-generation offspring of the Avon Longitudinal Study of Parents and Children.
Bell, Joshua A., Wade, Kaitlin H., O’Keeffe, Linda M., Carslake, David, Vincent, Emma E., Holmes, Michael V., Timpson, Nicholas J., Smith, George Davey   +7 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source