Results 241 to 250 of about 3,152,168 (304)

Access in all areas? A round up of developments in market access and health technology assessment: part 3. [PDF]

J Comp Eff Res
Beattie A, Treharne C, Ramagopalan SV.
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access. [PDF]

BioDrugs
Bittner B, Schmidt J.
europepmc   +1 more source

Electrolyte Additive Strategies in Aqueous Zn‐Ion Batteries: Recent Advances and Prospects

Advanced Science, EarlyView.
This article provides a comprehensive overview of the current status and future development directions of AZIBs electrolyte additives in three aspects: stabilizing zinc anodes (uniform deposition, inhibition of dendritic crystals), protecting cathodes (structural stability, inhibition of dissolution), and enhancing electrolyte stability (wider ...
Yuanze Yu, Hongmin Liu, Long Fan, Huakun Liu, Shixue Dou, Guoxiu Wang, Nana Wang, Zhongchao Bai   +7 more
wiley   +1 more source

Utilization of Bone-Anchored Annular Defect Closure to Prevent Reherniation Following Lumbar Discectomy: Overcoming Barriers to Clinical Adoption and Market Access. [PDF]

Int J Spine Surg
Lorio MP, Watters WC, Grunch BH, Metzger AK, Lewandrowski KU, Block JE, Andersson GBJ.   +6 more
europepmc   +1 more source

Transparent Photothermal Slippery Surface Based on Monolayer Self‐Assembled MXene Film for Anti‐Fogging and De‐Icing

Advanced Science, EarlyView.
The ultrathin (2.5 nm) MXene film self‐assembled at liquid interfaces breaks the trade‐off between transparency (82.5 %) and photothermal conversion effect (DT∼25.1°C ± 2.9 °C) under 100 mW cm−2. After encapsulated by a slippery surface with low adhesion, this transparent film can be applied in smart windows, eyewear, and optical sensors to autonomous ...
Xiao Han, Yiming Xie, Mingjia Sun, Di Zhao, Kesong Liu, Liping Heng, Lei Jiang   +6 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Correction: 'Do european regulatory measures accelerate national market access in Belgium? A retrospective analysis of medicines centrally authorised between 2015 and 2020'. [PDF]

BMJ Open
europepmc   +1 more source