Results 41 to 50 of about 1,651,023 (310)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Determinants of agricultural commercialization in Offa District, Ethiopia

Cogent Food & Agriculture, 2020
The Agricultural policies in Ethiopia to improve the commercial orientation of farmers require identification of challenges at farmer level and in-depth action to shift the sector.
Alula Tafesse, Guta Regasa Megerssa, Bogale Gebeyehu   +2 more
doaj   +1 more source

Production decisions and food security outcomes of smallholder’s livestock market participation: empirical evidence from Zimbabwe

Frontiers in Sustainable Food Systems, 2023
Smallholder market participation is an important pathway to improving the productivity and livelihoods of farm households. Despite several studies documenting the effect of market participation on crop production, relatively little is known about the ...
Mequanint B. Melesse, Amos Nyangira Tirra, Sabine Homann-Kee Tui, Sabine Homann-Kee Tui, Andre F. Van Rooyen, Michael Hauser, Michael Hauser   +6 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Factors affecting the intensity of market participation of smallholder sheep producers in northern Ethiopia: Poisson regression approach

Cogent Food & Agriculture, 2021
Sheep marketing is playing a great role in improving the livelihoods of smallholder farmers in Ethiopia. Although it plays a great role, the smallholder farmers are not sufficiently participating in the sheep market so they are poor.
Dubale Abate, Yonnas Addis
doaj   +1 more source

Analyzing the drivers of smallholder farmer’s market participation in the Sahelian region of Niger

Cogent Food & Agriculture, 2023
Many sub-Saharan farmers rely on agricultural production for home consumption and sell crops to meet their other needs. Farmers’ market intervention enhances economic expansion and helps to improve household food security. In our current study, we strive
Seydou Zakari, Bokar Moussa, Germaine Ibro, Tahirou Abdoulaye   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Analysing the Factors that Influence Market Participation among Avocado Producers in Kaffa Zone of South-Western Ethiopia

International Journal of Fruit Science, 2022
Market participation by smallholder farmers is crucial for livelihood improvement in developing countries. Even though it is the source of currency, the fruit market has not been given attention.
Nigus Gurmis, Tsegaye Melese
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source