Results 111 to 120 of about 1,120,895 (312)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

THE ROLE OF THE MARKETING MIX IN CONCEIVING THE STRATEGIC OPTIONS FOR THE COUNTY MUSEUM OF BOTOSANI [PDF]

Museums are institutions that collect, research, promote and interpret objects (Sandell and Janes, 2007). It was insisted on the idea that the whole existence of the museums depends on the possession of a collection (McLean, 1994). While the collection’s
Razvan-Andrei CORBOS, Ruxandra Irina POPESCU   +1 more
core  

ESTABLISHING AN AGRIBUSINESS STUDY ABROAD COURSE IN MEXICO: A PROJECT IN INTERNATIONALIZING THE CURRICULUM [PDF]

Study abroad provides students with a cross-cultural experience and a new perspective on the global market place. Seven students from the University of Georgia enrolled in an initial course entitled , International Agribusiness Marketing and Management ...
Ames, Glenn C.W., Houston, Jack E.
core   +4 more sources

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Internationalization of Large Retailers and Cross-Cultural Determinants – The Singular Trajectory of Carrefour in Romania [PDF]

This article discusses the large retailers’ internationalization strategy. It deals more particularly with the way in which international expansion proceeds on the level of operations management and the application of strategies used on the domestic ...
Francois CASSIERE, Gilles PACHE
core  

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

MARKETING MANAGEMENT: AN APPROACH BASED ON THE DEFINITION AND CONSIDERATION OF CORPORATE CULTURE

Aktualʹnì Problemi Rozvitku Ekonomìki Regìonu
The article comprehensively examines the interplay between marketing management and corporate culture within today's business environment. The research design combines a critical review of the pertinent scholarly literature with logical modelling of the "
K. Balakleiets, A. Kovalevska
doaj   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Enhancing visitor experiences: a quantitative analysis of marketing strategies at historical and cultural national parks

Cogent Social Sciences
This study explores the impact of marketing mix elements—product, price, process, physical evidence, people, place, and promotion—on customers’ revisit potential to cultural and historical national parks.
Rumpapak Luekveerawattana
doaj   +1 more source