Results 51 to 60 of about 1,254,656 (291)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

A Start to finish guide to opening a bed & breakfast: The business plan.

open access: yes, 2010
Background Beds and breakfast are the small business component of the hotel industry. Like all types of small businesses, many fail due to poor planning or misguided management. As more new entrepreneurs enter the market due to the decline of the economy
Fredette, Ellen A.
core   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock   +4 more
wiley   +1 more source

Extensiveness of business planning and firm survival: an examination into the drivers of success and survival for knowledge intensive start-up firms [PDF]

open access: yes, 2010
A number of studies have found that writing a business plan increases the likelihood of firm survival. For instance, Liao and Gartner (2006) found that firms that completed a business plan were nearly three times more likely to launch their business than
Englis, Basil G.   +4 more
core   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer   +5 more
wiley   +1 more source

Marketing Plan (1993) [PDF]

open access: yes, 1993
"Reviewed October 1, 1993."A marketing plan is probably both the most important and least thought of aspect of a new business. Without a marketing plan, (1) product or service acceptance is normally far below potential, (2) promotional dollars are spent ...
Amos, John M., Drexler, Jim
core  

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

open access: yesArthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr   +5 more
wiley   +1 more source

MANAGEMENT OF A MARKETING PLAN [PDF]

open access: yesFiabilitate şi Durabilitate, 2018
For almost all products there is a very important stage after the design, manufacture and control process: industrial marketing activity. This is the basis for promoting and assessing the requirements of beneficiaries and consumers so that they are ...
Andrei DIMITRESCU   +4 more
doaj  

Jelly Candies with Apple Pomace—A Circular Economy Solution for a Food Processing Waste

open access: yesAgriculture
Apple juice processing by-product (apple pomace), considered as waste that generates important pollution problems, is also a rich source of bioactive compounds, including minerals, dietary fibers, phenolic compounds, and vitamins.
Iuliana-Maria Enache   +4 more
doaj   +1 more source

Marketing plan development [PDF]

open access: yes, 2014
Treball Final de Grau en Administració d'Empreses. Codi: AE1049. Curs 2013-2014In the actually, we are in a context of economical crisis, when the exterior sector in Spain is one of the few sector that has an increase in their sales.
Syouffi Barghout, Durry
core  

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