Results 111 to 120 of about 68,126 (238)

Steering semi-flexible molecular diffusion model for structure-based drug design with reinforcement learning. [PDF]

open access: yesSci Adv
Zhang X   +10 more
europepmc   +1 more source

Neural barcoding representing cortical spatiotemporal dynamics based on continuous-time Markov chains. [PDF]

open access: yesCell Rep Methods
Culp JM   +5 more
europepmc   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Vagus Nerve Stimulation Paired With Tones Alters the Auditory Cortex Proteome in a Rat Model of Rett Syndrome

open access: yesDevelopmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers   +6 more
wiley   +1 more source

A Survey for Deep Reinforcement Learning Based Network Intrusion Detection

open access: yesApplied AI Letters, Volume 7, Issue 2, June 2026.
This paper surveys deep reinforcement learning (DRL) for network intrusion detection, evaluating model efficiency, minority attack detection, and dataset imbalance. Findings show DRL achieves state‐of‐the‐art results on public datasets, sometimes surpassing traditional deep learning.
Wanrong Yang   +3 more
wiley   +1 more source

On MAP Estimates and Source Conditions for Drift Identification in SDEs

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT We consider the inverse problem of identifying the drift in an stochastic differential equation (SDE) from n$n$ observations of its solution at M+1$M+1$ distinct time points. We derive a corresponding maximum a posteriori (MAP) estimate, we prove differentiability properties as well as a so‐called tangential cone condition for the forward ...
Daniel Tenbrinck   +3 more
wiley   +1 more source

Genetic identification and characterization of novel loci for flag leaf morphology traits in Chinese endemic wheat

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Flag leaf morphology (FLM) is a critical determinant of wheat (Triticum aestivum L.) photosynthetic efficiency and grain yield. Chinese endemic wheat, a unique genetic reservoir formed by long‐term adaptation to diverse and heterogeneous environments in China, harbors abundant, untapped allelic variation for traits related to environmental ...
Md Nahibuzzaman Lohani   +12 more
wiley   +1 more source

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