Results 111 to 120 of about 1,485 (251)

Markov Blanket Density and Free Energy Minimization

CoRR
This paper presents a continuous, information-theoretic extension of the Free Energy Principle through the concept of Markov blanket density, i.e., a scalar field that quantifies the degree of conditional independence between internal and external states at each point in space (ranging from 0 for full coupling to 1 for full separation). It demonstrates
openaire   +2 more sources

Tracheal chambers as a key innovation for high‐frequency emission in bat echolocation

The Anatomical Record, EarlyView.
Abstract Key innovations are pivotal for biodiversity and facilitating evolutionary success, enabling organisms' adaptation to various ecological niches through the diversification of phenotypic traits. In mammals, notable adaptations include evolving hypsodonty for grazing on grasses and, for bats, evolving echolocation and wing acquisition.
Nicolas L. M. Brualla, Laura A. B. Wilson, Khizar Hayat, Michael Doube, Vuong Tan Tu, Thongchai Ngamprasertwong, Thanakul Wannaprasert, Daisuke Koyabu   +7 more
wiley   +1 more source

Evolutionary morphology of the haplorhine hamate

The Anatomical Record, EarlyView.
Abstract Primates adopt a variety of hand postures during an impressive diversity of locomotor and manipulative behaviors. Morphological research has found that elements of the hand skeleton, such as the hamate, hold key information for inferring hand use and locomotor kinematics in extinct species.
Laura E. Hunter, Matthew W. Tocheri, Caley M. Orr, Biren A. Patel, Zeresenay Alemseged   +4 more
wiley   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Feature selection and prediction with a Markov blanket structure learning algorithm [PDF]

BMC Bioinformatics, 2013
Tan Y, Liu Z.
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data. [PDF]

BMC Genet, 2016
Li H, Yuan Z, Ji J, Xu J, Zhang T, Zhang X, Xue F.   +6 more
europepmc   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Causality-driven feature selection and domain adaptation for enhancing chemical foundation models in downstream tasks

Machine Learning: Science and Technology
Recent advancements in large foundation models have revealed impressive capabilities in mastering complex chemical language representations. These models undergo a task-agnostic learning phase, characterized by pre-training on extensive unlabeled corpora
Eduardo Soares, Victor Yukio Shirasuna, Emilio Vital Brazil, Karen Fiorella Aquino Gutierrez, Renato Cerqueira, Dmitry Zubarev, Kristin Schmidt, Daniel P Sanders   +7 more
doaj   +1 more source