Results 231 to 240 of about 1,853,662 (312)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre   +5 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou   +4 more
wiley   +1 more source

Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model

open access: yesPackaging Technology and Science, EarlyView.
A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas   +3 more
wiley   +1 more source

VAE‐Based SPC for Botnet Detection in IoT Systems

open access: yesQuality and Reliability Engineering International, EarlyView.
ABSTRACT The rapid proliferation of Internet of Things (IoT) devices has created new security risks, particularly botnet infections. This paper proposes an unsupervised monitoring framework that combines a β$\beta$‐variational autoencoder (VAE) with multivariate statistical process control (SPC) for botnet detection in IoT networks.
Jorge Proaño   +3 more
wiley   +1 more source

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