Results 101 to 110 of about 60,582 (310)
Arthritis &Rheumatology, EarlyView.Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen +23 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Non-homogeneous Markov chains with a finite state space and a Doeblin type theorem
International Journal of Mathematics and Mathematical Sciences, 1995 Doeblin [1] considered some classes of finite state nonhomogeneous Markov chains and studied their asymptotic behavior. Later Cohn [2] considered another class of such Markov chains (not covered earlier) and obtained Doeblin type results.
Rita Chattopadhyay
doaj +1 more source
Equivalent Conditions for Irreducibility of Discrete Time Markov Chains [PDF]
We consider discrete time Markov chains on general state space. It is shown that a certain property referred to here as nondecomposability is equivalent to irreducibility, and that a Markov chain with invariant distribution is irreducible if and only if ...
Cuong Le Van, John Stachurski
core
Stochastic monotonicity and duality for one-dimensional Markov processes [PDF]
, 2011 The theory of monotonicity and duality is developed for general one-dimensional Feller processes, extending the approach from [11]. Moreover it is shown that local monotonicity conditions (conditions on the Lévy kernel) are sufficient to prove the well-
Kolokoltsov, V. N. (Vasiliĭ Nikitich)
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British Journal of Clinical Pharmacology, EarlyView.Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas +16 more
wiley +1 more source
Portfolio optimization by applying Markov chains [PDF]
Anali Ekonomskog fakulteta u Subotici, 2018 Since one of the main problems in today's economy is 'conquering the market' or, in other words, finding the best way to predict price movements and receive expected rates of return, this paper will deal with the portfolio optimization in the Belgrade ...
Petković Nina +2 more
doaj
First passage of a Markov additive process and generalized Jordan chains [PDF]
In this paper we consider the first passage process of a spectrally negative Markov additive process (MAP). The law of this process is uniquely characterized by a certain matrix function, which plays a crucial role in fluctuation theory.
Michel Mandjes +3 more
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Advances in causal discovery methods for ecological time series
Biological Reviews, EarlyView.ABSTRACT Recent advances in data collection technologies (e.g. automated sensor networks, satellite remote sensing, and high‐throughput sequencing) have greatly expanded the availability of ecological time series, enabling new opportunities for causal analyses in dynamic ecosystems.
Kenta Suzuki +6 more
wiley +1 more source