Results 101 to 110 of about 48,213 (289)

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model. [PDF]

JHEP Rep, 2021
Zhang S, Suen SC, Gong CL, Pham J, Trebicka J, Duvoux C, Klein AS, Wu T, Jalan R, Sundaram V.   +9 more
europepmc   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Optimal treatment recommendations for diabetes patients using the Markov decision process along with the South Korean electronic health records. [PDF]

Sci Rep, 2021
Oh SH, Lee SJ, Noh J, Mo J.
europepmc   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

Biotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman, Emily Lathrop, Aurelia Attal‐Juncqua, Matthew Nicotra, Allison Berke   +4 more
wiley   +1 more source

Aircraft Flight Autonomous Decision-Making Method Based on Target Predicted Trajectory and Markov Decision Process

Actuators
In this paper, in order to enhance the autonomous operation capabilities of aircraft and ensure their operational safety and efficiency, we propose an autonomous decision-making framework based on target motion state prediction combined with the Markov ...
Yang Zhou, Xinmin Tang, Xuanming Ren
doaj   +1 more source

Contralateral exploration and repair of occult inguinal hernias during laparoscopic inguinal hernia repair: systematic review and Markov decision process. [PDF]

BJS Open, 2021
Dhanani NH, Olavarria OA, Wootton S, Petsalis M, Lyons NB, Ko TC, Kao LS, Liang MK.   +7 more
europepmc   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

Continual decision‐making dynamics across biological organisms

Biological Reviews, EarlyView.
ABSTRACT Decision‐making is a central function of adaptive behaviour in biological agents. However, strategies for adaptive decision‐making can vary substantially across species. Here, we aim to extend the comparative scope of decision‐making analyses to phylogenetically diverse organisms.
Liberty Severs, Qiuran Wang
wiley   +1 more source

Research on constellation fault satellite replacement strategy based on Markov decision process

Hangkong gongcheng jinzhan
With the decrease of the importance of single satellite caused by the large-scale constellation，multiple replacement methods and the retention of faulty satellites should be considered when formulating the replacement strategy of faulty satellites.
LIN Ruoyu, FENG Yunwen, XUE Xiaofeng, ZHENG Xiaoyan, CUI Shuai   +4 more
doaj   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, EarlyView.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source