Advanced Science, Volume 13, Issue 44, 7 August 2026.SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
Cooperative Tracking of Vessel Trajectory by Multi-Static Passive Stations Using an MC-RMPF. [PDF]
Sensors (Basel)Liu B, Kong L, Wu P.
europepmc +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, Volume 13, Issue 46, 17 August 2026.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
An Entropy-Based Framework for Hybrid Coalitions in Game Theory-Part I: Human Arbitration. [PDF]
Entropy (Basel)Sepúlveda-Fontaine SA, Amigó JM.
europepmc +1 more source
Deep Learning‐Assisted Coherent Raman Scattering Microscopy
Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu +4 more
wiley +1 more source
Research on coupling coordination of new quality productive forces and innovation resource allocation based on MLP neural networks. [PDF]
Sci RepLiu Y, Wang L, Chen B, Shan H.
europepmc +1 more source
Advanced Experiment Design Strategies for Drug Development
Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang +3 more
wiley +1 more source
Regional disparities, dynamic evolution, and convergence of China's resident health service development levels. [PDF]
BMC Health Serv ResShao X, Wu Z.
europepmc +1 more source
Altered Evening Aperiodic Activity and Microstate Dynamics in Insomnia Disorder: An OPM MEG Study
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.Using wearable OPM‐MEG, this study characterized evening and morning resting state neurophysiology in insomnia disorder. A flatter evening aperiodic spectral exponent suggested relatively elevated cortical excitability, alongside altered microstate dynamics involving putative limbic and sensorimotor network states.
Feng Cui +13 more
wiley +1 more source
Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins. [PDF]
Proc Natl Acad Sci U S AKlimek A, Dalton BA, Tepper L, Netz RR.
europepmc +1 more source