Results 151 to 160 of about 123,643 (248)

Simplifying species‐interaction models by grouping parameters: optimal groupings differ between effects and responses

open access: yesOikos, EarlyView.
Most ecological models of species interactions require many parameters, making them expensive to fit to experimental or observational data. To reduce the number of parameters, species are often divided into groups a priori, for example on the basis of functional or phylogenetic similarity, and species within these groups are assumed to behave ...
Christopher R. P. Brown   +1 more
wiley   +1 more source

Connecting the distribution and diversification of marine plants

open access: yesOikos, EarlyView.
Integration of the evolutionary history with distribution of extant species is necessary to explain present‐day diversity, particularly for ‘foundation' species, such as seagrasses, which create habitats of socioecological relevance. Here, we resolved if varying evolutionary history of seagrass families has imprinted the distribution ranges of extant ...
Fernando Tuya   +3 more
wiley   +1 more source

Beyond our backyard: Unravelling how social‐ecological fit drives the formation of inter‐regional collaborative networks for water governance in the Yellow River Basin

open access: yesPeople and Nature, EarlyView.
Abstract The societal and biophysical permeability across human‐demarcated jurisdictions within watersheds necessitates collaboration among administrative regions. The effectiveness of such collaboration is partly determined by the degree to which institutional arrangements align with underlying social and ecological interdependencies, a concept ...
Fang Wang   +3 more
wiley   +1 more source

Detecting extirpation: A localized approach to a global problem

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
The global biodiversity crisis stems from a cascading series of extirpations driving species toward extinction. Addressing this crisis requires methods for early detection of extinction at local scales, where communities can mobilize conservation efforts.
Andrew D. F. Simon   +4 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou   +4 more
wiley   +1 more source

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