CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley +1 more source
Asynchronous Non-Fragile <i>H</i><sub>∞</sub> Control for Time-Delay Markovian Jump Singularly Perturbed Systems with Variable Quantization Density and DoS Attack. [PDF]
Entropy (Basel)Qin Y, Wu X, Xiao H, Huang L, Lu Y.
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OPERATOR METHODS, ABELIAN PROCESSES AND DYNAMIC CONDITIONING [PDF]
A mathematical framework for Continuous Time Finance based on operator algebraic methods oers a new direct and entirely constructive perspective on the field.
Albanese, Claudio
core
Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou +4 more
wiley +1 more source
Cloud-Edge Collaborative Personalized Deployment of Knowledge Bases in Semantic Communications. [PDF]
Sensors (Basel)Yang K, Han Y, Xu Y, Chen M.
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Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model
Packaging Technology and Science, EarlyView.A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas +3 more
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Stochastic Reaction Networks Within Interacting Compartments with Content-Dependent Fragmentation. [PDF]
Bull Math BiolAnderson DF, Howells AS, La Luz DR.
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The existence and characterisation of duality of Markov processes in the Euclidean space [PDF]
This thesis examines the existence of dualMarkov processes and presents the full characterization of Markov processes in Euclidean space equipped with the natural order (the Pareto order).
Lee, Rui Xin
core
Quality and Reliability Engineering International, EarlyView.ABSTRACT A repairable system operates under a maintenance strategy involving scheduled preventive maintenance (PM) and corrective repair actions following failures. This study develops an exact analytical methodology using Markov chains with discrete states and time to calculate the expected number of failures E[N(t)]$\mathop {\mathbb {E}}[N(t)]$ under
Danilo G. O. Valadares +3 more
wiley +1 more source
Double event-triggered fault tolerant consensus of nonlinear heterogeneous multiagent systems under inconsistent Markov. [PDF]
Sci RepHu D, Ma J, Zang S.
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