Results 121 to 130 of about 6,497 (242)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

Unravelling Cascading Phenomena in Sociotechnical Systems: A Systematic Review and Modelling Framework

open access: yesSystems Research and Behavioral Science, EarlyView.
ABSTRACT This article investigates the characterization of cascading phenomena within sociotechnical systems through a systematic review and the development of a conceptual modelling framework. Cascading phenomena, often described using terms such as ripple effect, domino effect, cascading failure, risk propagation and cascading effect, capture the far‐
Jiayao Li   +7 more
wiley   +1 more source

DQN‐Guided Subset‐Induced OCSVM Kernel Approximation for Imbalanced Anomaly Detection

open access: yesIEEJ Transactions on Electrical and Electronic Engineering, EarlyView.
Anomaly detection under limited normal data remains a fundamental challenge due to severe class imbalance and scarcity of anomalies. We propose a novel framework that reformulates support vector selection in One‐Class SVM as a sequential decision‐making problem.
Wenqian Yu, Jiaying Wu, Jinglu Hu
wiley   +1 more source

Narrow band imaging‐guided diode laser ablation in recurrent low‐grade non‐muscle‐invasive bladder cancer

open access: yesUroPrecision, EarlyView.
Abstract Background Low‐grade non‐muscle‐invasive bladder cancer (NMIBC) is characterized by high recurrence rates, resulting in repeated interventions and intensive surveillance. Office‐based transurethral laser ablation (TULA) performed under local anesthesia is a minimally invasive alternative to transurethral resection, and narrow band imaging (NBI)
Ibrahim A. Khalil   +6 more
wiley   +1 more source

Reinforcement Learning With Timed Constraints for Robotics Motion Planning

open access: yesArtificial Intelligence for Engineering, EarlyView.
This work presents a unified automata‐based reinforcement learning framework that enforces MITL time‐bounded task specifications in both MDPs and POMDPs. Results from grid‐world and office scenarios show robust policy learning under stochastic dynamics and partial observability.
Zhaoan Wang   +3 more
wiley   +1 more source

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