Results 11 to 20 of about 13,374 (188)
Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy. [PDF]
Aging CellHumanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Jang HY +7 more
europepmc +2 more sources
Early development of the cochlea of the common marmoset, a non-human primate model
Neural Development, 2022 Background Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents.
Makoto Hosoya +5 more
doaj +1 more source
PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease. [PDF]
PLoS ONE, 2012 BACKGROUND: Positron Emission Tomography (PET) measurement was applied to the brain of the common marmoset, a small primate species, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Kiyoshi Ando +8 more
doaj +1 more source
Stem Cell Research, 2021 POU class 5 homeobox 1 (POU5F1, also known as OCT4) is critical for maintenance of pluripotency, germ cell fate, reprogramming into a pluripotent state, and early embryogenesis.
Sho Yoshimatsu +7 more
doaj +1 more source
A natural marmoset model of genetic generalized epilepsy
Molecular Brain, 2022 Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment.
Xiangyu Yang +10 more
doaj +1 more source
eLife, 2019 Understanding the connectivity architecture of entire vertebrate brains is a fundamental but difficult task. Here we present an integrated neuro-histological pipeline as well as a grid-based tracer injection strategy for systematic mesoscale connectivity
Meng Kuan Lin +14 more
doaj +1 more source
Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach. [PDF]
PLoS ONE, 2015 Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins.
Katharina Debowski +8 more
doaj +1 more source
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
atlasBREX: Automated template-derived brain extraction in animal MRI
Scientific Reports, 2019 We proposed a generic template-derived approach for (semi-) automated brain extraction in animal MRI studies and evaluated our implementation with different animal models (macaque, marmoset, rodent) and MRI protocols (T1, T2).
Johannes Lohmeier +4 more
doaj +1 more source
Iranian Journal of Parasitology, 2019 Background: Recently, the use of common marmoset (Callithrix jacchus) has increased in biomedical research as an animal model. This study aimed to test fecal samples to monitor bacterial and parasite infections in common marmoset at the Laboratory Animal
Eui-Suk JEONG +7 more
doaj +1 more source