Results 31 to 40 of about 30,879 (234)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Genomic skimming and nanopore sequencing uncover cryptic hybridization in one of world’s most threatened primates

Scientific Reports, 2021
The Brazilian buffy-tufted-ear marmoset (Callithrix aurita), one of the world’s most endangered primates, is threatened by anthropogenic hybridization with exotic, invasive marmoset species. As there are few genetic data available for C.
Joanna Malukiewicz, Reed A. Cartwright, Jorge A. Dergam, Claudia S. Igayara, Patricia A. Nicola, Luiz M. C. Pereira, Carlos R. Ruiz-Miranda, Anne C. Stone, Daniel L. Silva, Fernanda de Fatima Rodrigues da Silva, Arvind Varsani, Lutz Walter, Melissa A. Wilson, Dietmar Zinner, Christian Roos   +14 more
doaj   +1 more source

To Merge or not: The Early Onto- and Phylogenetic Origin of Co-Representation. [PDF]

Dev Sci
ABSTRACT The origin of co‐representation during joint action poses a puzzle: It apparently only emerges around the age of four in humans, suggesting it is cognitively demanding, but has also been demonstrated in several nonhuman primate species whose cognitive skills do not match human four‐year‐olds.
Miss FM, Santharuban L, Willems EP, Burkart JM.   +3 more
europepmc   +2 more sources

Evaluating depression- and anxiety-like behaviors in non-human primates

Frontiers in Behavioral Neuroscience, 2023
Depression and anxiety are some of the most prevalent and debilitating mental health conditions in humans. They can present on their own or as co-morbidities with other disorders. Like humans, non-human primates (NHPs) can develop depression- and anxiety-
Karla K. Ausderau, Karla K. Ausderau, Karla K. Ausderau, Ricki J. Colman, Ricki J. Colman, Sabrina Kabakov, Nancy Schultz-Darken, Marina E. Emborg, Marina E. Emborg   +8 more
doaj   +1 more source

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]

, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa, Chee, Sora, Chi, Neil C, Destici, Eugin, Evans, Sylvia M, Fang, Rongxin, Farah, Elie N, Grinstein, Jonathan D, Hu, Rong, Huang, Hui, Izpisua Belmonte, Juan Carlos, Lee, Ah Young, Li, Ting, Ma, Kaiyue, Preissl, Sebastian, Qiu, Yunjiang, Ren, Bing, Wu, Jun, Ye, Zhen, Yu, Leqian, Zhang, Yanxiao, Zhu, Quan   +21 more
core   +2 more sources

LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing. [PDF]

PLoS ONE, 2012
Increasing incidence and substantial morbidity and mortality of respiratory diseases requires the development of new human-specific anti-inflammatory and disease-modifying therapeutics.
Sophie Seehase, Hans-Dieter Lauenstein, Christina Schlumbohm, Simone Switalla, Vanessa Neuhaus, Christine Förster, Hans-Gerd Fieguth, Olaf Pfennig, Eberhard Fuchs, Franz-Josef Kaup, Martina Bleyer, Jens M Hohlfeld, Armin Braun, Katherina Sewald, Sascha Knauf   +14 more
doaj   +1 more source

Age exacerbates the effect of myopia on retinal capillaries and string vessels

Frontiers in Medicine, 2023
The retinal vasculature supplies oxygen and nutrition to the cells and is crucial for an adequate retinal function. In myopia, excessive eye growth is associated with various anatomical changes that can lead to myopia-related complications.
Carol Ren Lin, Abduqodir Toychiev, Reynolds Kwame Ablordeppey, Miduturu Srinivas, Alexandra Benavente-Perez   +4 more
doaj   +1 more source

Building Babies - Chapter 16 [PDF]

, 2012
In contrast to birds, male mammals rarely help to raise the offspring. Of all mammals, only among rodents, carnivores, and primates, males are sometimes intensively engaged in providing infant care (Kleiman and Malcolm 1981).
A Fuentes, A Goldizen, A Gozalo, A Morcillo, A Paul, A Savage, AC Keddy Hector, AF Dixson, AF Dixson, AI Houston, AI Houston, AI Houston, AJ Bateman, AK Birnie, AM Hurtado, AW Goldizen, AW Goldizen, AW Goldizen, B Jantschke, BB Smuts, BC Sheldon, BC Trainor, BC Trainor, BS Hewlett, BS Hewlett, C Ross, C Schradin, C Schradin, C Welker, CK Wolovich, CK Wolovich, CK Wolovich, CM Anderson, CM Drea, CM Nievergelt, CR Pryce, CT Snowdon, DC Geary, DC Geary, DG Kleiman, DJ Gubernick, DK Brockmann, DM Fragaszy, DS Sherry, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, E Fernandez-Duque, EC Price, EC Price, EC Price, EC Price, ED Starin, ED Starin, ER Patel, EW Heymann, F Marlowe, F Marlowe, FB Bercovitch, GA Parker, GG Achenbach, H Kokko, HG Erkert, HS Morland, J Allman, J Itani, J Mitani, J Moreno, JA Stallcup, JC Buchan, JC Mitani, JC Wingfield, JE Fite, JK Martin, K Hirschenhauser, KA Hoffman, KAI Nekaris, KG Anderson, KL Bales, KL Bales, KL Kramer, KL Wuensch, KM Kostan, LM Porter, LM Porter, LT Gettler, LT Gettler, M Huck, M Huck, M Huck, M Huck, M Rotundo, MA Norconk, ME Yamamoto, MF Small, MJ Wade, MJ Wade, MJE Charpentier, ML Bastian, ML Rafacz, N Nicolson, NG Solomon, P Löttker, PA Garber, PA Garber, PB Gray, PC Wright, PC Wright, PC Wright, PE Komers, PL Whitten, PM Kappeler, PM Kappeler, R Dawkins, R Härdling, R Palombit, RA Fisher, RIM Dunbar, RJ Hoage, RL Trivers, S Gursky, S Lappan, S Maynard Smith, S Perry, S Sánchez, S Tardif, SA Kingma, SB Hrdy, SD Tardif, SN Austad, SP Mendoza, SR Tecot, TE Ziegler, TE Ziegler, TE Ziegler, TE Ziegler, TG O’Brien, TH Clutton-Brock, TR Harris, U Reichard, W Goymann, W Leutenegger, W Wickler, WC McGrew, ZF Xiang   +150 more
core   +2 more sources

The occurrence of ureaplasmas in marmosets [PDF]

Laboratory Animals, 1976
Ureaplasmas were isolated from the oropharynx of all of 22 male and 19 female adult marmosets and from the genital tract of about a quarter of them. These ureaplasmas seem to be natural inhabitants of the oropharynx and not of human origin because half the animals had had very limited human contact and preliminary serological tests indicate that the ...
P M, Furr, D, Taylor-Robinson, C M, Hetherington   +2 more
openaire   +2 more sources

In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis

eLife, 2023
Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu, Nathanael J Lee, María I Gaitán, Seung-Kwon Ha, Nicholas J Luciano, Snehashis Roy, Benjamin Ineichen, Emily C Leibovitch, Cecil C Yen, Dzung L Pham, Afonso C Silva, Mac Johnson, Steve Jacobson, Pascal Sati, Daniel S Reich   +14 more
doaj   +1 more source