Results 161 to 170 of about 8,068 (254)

Marrows, Christopher H

, 2016
Marrows, Christopher H
core  

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Mosaic Inverted Hemagglutinin Extracellular Vesicle Vaccines Elicit Protective Systemic and Mucosal Immunity against Heterosubtypic Influenza Infection. [PDF]

ACS Nano
Zhu W, Wei L, Dong C, Kim JK, Bruhn M, Ma Y, Ferrante A, Arsana A, Omotara P, Kang SM, Wang BZ.   +10 more
europepmc   +1 more source

Marrows, C. H.

, 2016
Marrows, C. H.
core  

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Immune intervention is dispensable for retinoic acid/ arsenic therapy of murine acute promyelocytic leukemia. [PDF]

Haematologica
Esnault C, Fortin G, Qiu F, Soilihi H, Souquère S, Niwa-Kawakita M, Lanchais K, Dirami T, Pierron G, De Thé H.   +9 more
europepmc   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model. [PDF]

J Biomed Sci
Chan SH, Lin CY, Tseng HJ, Wang LH.
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells. [PDF]

Nat Cancer
Pathak A, Sravya P, Colon B, Ciervo E, Zhou Y, Teran Pumar OY, León BE, Mitchell J, Assenza Tavares Coroa PH, Mateo-Victoriano B, Scott AJ, Gannamedi DP, Wong HKA, Zhang L, Lee J, Kay K, Karaca E, Chin DH, Amirian H, Karaman I, Shrestha P, Sellick K, Dean D, Bilbao Cortes D, Datta J, Welford SM, Franco MC, Kurmi K, Shah AH, Cheng F, Lathia JD, Rai P, Lombard DB, Lyssiotis CA, Watson DC, Ceccarelli M, Wahl DR, Bayik D.   +37 more
europepmc   +1 more source