Results 171 to 180 of about 8,068 (254)

Courgette marrows for the mass culture of some nematodes.

, 1988
Hooper, D. J., Cowland, J. A.
core  

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Decreased expression of BCL2 protein on the diagnostic bone marrow T cells in adult acute myeloid leukemia. [PDF]

Sci Rep
Shi ZY, Sun K, Wang YZ, Xie DH, Li ZY, Jiang Q, Jiang H, Qin YZ.   +7 more
europepmc   +1 more source

Courgette marrows (squash) for the mass culture of some nematodes.

, 1988
Hooper, D. J.
core  

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish. [PDF]

Nat Aging
Morabito G, Dönertas HM, Sperti L, Seidel J, Poursadegh Zonouzi A, Poeschla M, Valenzano DR.   +6 more
europepmc   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Synergistic cooperation between progranulin and Jak2/Stat3 signaling determines definitive myeloid cell fate. [PDF]

Cell Rep
McCune A, Usha MK, Baldus I, Willett CJ, Ferrito N, Barakat R, Clemensen E, Snella E, Morton M, Lacal J, Pavani G, Campbell CA, Espin-Palazon R.   +12 more
europepmc   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

A pan-cancer single-cell transcriptomic atlas of human bone metastases. [PDF]

Cell Rep Med
Wang S, Ma F, Wang D, Yu Q, Zheng H, Chen Z, Zhao S, Xu L, Ye Q, Tan Y, Huang W, Sun Z, Wu Z, Cai W, Fang M, Cheng M, Ji Y, Zhang Y, Gu B, Song S, Chen Y, Zhang J, Shao Y, Yan W, Sun Y.   +24 more
europepmc   +1 more source