Results 71 to 80 of about 660,114 (325)

Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

Leukemia, 2020
Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid malignancies, require investigation and countermeasures. Both are nucleoside analog pro-drugs processed by pyrimidine metabolism into a deoxynucleotide analog that ...
X. Gu, R. Tohme, B. Tomlinson, Nneha Sakre, M. Hasipek, Lisa Durkin, Caroline Schuerger, D. Grabowski, Asmaa M. Zidan, T. Radivoyevitch, Changjin Hong, H. Carraway, B. Hamilton, R. Sobecks, B. Patel, B. Jha, E. Hsi, J. Maciejewski, Y. Saunthararajah   +18 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Anisotropic magnetoresistance contribution to measured domain wall resistances of in-plane magnetised (Ga,Mn)As

, 2006
We demonstrate the presence of an important anisotropic magnetoresistance contribution to the domain wall resistance recently measured in thin-film (Ga,Mn)As with in-plane magnetic anisotropy.
Bending, S. J., Crampin, S., Roberts, H. G.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3 [PDF]

, 2017
In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages.
Atolagbe, Oluwatomisin T., Birnbaumer, Lutz, Joe, Bina, Kumarasamy, Sivarajan, Solanki, Sumeet, Vazquez, Guillermo   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Diversity enabling equilibration: disorder and the ground state in artificial spin ice

, 2011
We report a novel approach to the question of whether and how the ground state can be achieved in square artificial spin ices where frustration is incomplete.
Budrikis, Zoe, Politi, Paolo, Stamps, R. L.   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Focus on artificial frustrated systems

New Journal of Physics, 2014
Frustration in physics is the inability of a system to simultaneously satisfy all the competing pairwise interactions within it. The past decade has seen an explosion of activity involving engineering frustration in artificial systems built using ...
J Cumings, L J Heyderman, C H Marrows, R L Stamps   +3 more
doaj   +1 more source

Os cordis of mature Dromedary camel heart (Camelus dromedaries) with special emphasis on cartilago cordis

Journal of Advanced Veterinary and Animal Research, 2014
The present study was conducted to investigate the bony structure (i.e., os cordis) in the heart of mature Dromedary camel. Ten hearts were collected from healthy mature camels of both sexes aging between 7-9 years. Grossly, the heart contained one large,
Ahmad Balah, Mohamed Hafez Bareedy, Ahmad Awad Abuel-Atta, Wael Ghonimi   +3 more
doaj   +1 more source