Results 61 to 70 of about 1,349,667 (249)
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Problems with studying topology of the universe via circles from cosmic microwave background data [PDF]
arXiv, 2004 This paper has been withdrawn by the authors for future revision.
arxiv
Global optimization using mixed integer quadratic programming on non-convex two-way interaction truncated linear multivariate adaptive regression splines [PDF]
arXiv, 2020 Multivariate adaptive regression splines (MARS) is a flexible statistical modeling method that has been popular for data mining applications. MARS has also been employed to approxmiate unknown relationships in optimzation for complex systems, including surrogate optimization, dynamic programming, and two-stage stochastic programming.
arxiv
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
Mars Science Laboratory Observations of the 2018/Mars Year 34 Global Dust Storm
Geophysical Research Letters, 2018 Mars Science Laboratory Curiosity rover observations of the 2018/Mars year 34 global/planet‐encircling dust storm represent the first in situ measurements of a global dust storm with dedicated meteorological sensors since the Viking Landers.
S. Guzewich +24 more
semanticscholar +1 more source
Archimedean Type Conditions in Categories [PDF]
arXiv, 2008 Two concepts of being Archimedean are defined for arbitrary categories.
arxiv
Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma
Molecular Oncology, EarlyView.Ewing sarcoma is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF complex via ARID1A. ARID1A's ability to form biomolecular condensates is crucial for tumor growth, making it a potential therapeutic target. However, targeting these transient condensates is challenging, requiring further research. Ewing sarcoma,
Erich J. Sohn, David S. Libich
wiley +1 more source
Clay mineral diversity and abundance in sedimentary rocks of Gale crater, Mars
Science Advances, 2018 Clay minerals found in Gale crater, Mars, record surficial chemical weathering and changing conditions in an ancient lake. Clay minerals provide indicators of the evolution of aqueous conditions and possible habitats for life on ancient Mars. Analyses by
T. Bristow +25 more
semanticscholar +1 more source
Axiomatic Differential Geometry I-1 [PDF]
arXiv, 2012 In this paper we give an axiomatization of differential geometry comparable to model categories for homotopy theory. Weil functors play a predominant role.
arxiv
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source