Results 71 to 80 of about 473,493 (245)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
metagenomics taxa tables, source data for metabolomics, human transcriptome and cytokine ...
Mars, R
core +1 more source
Analysis of Mars data using Arcobjects and Modelbuilder [PDF]
, 2007 Geographic Information Systems (GIS) are powerful tools for integration of different planetary datasets, e.g. images, spectral data, and digital terrain models which are typically given in different formats like vector and raster.
Saiger, Peter +5 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Unlocking the circular economy potential of spent dialysate in hemodialysis
NefrologíaSpent dialysate, a byproduct of hemodialysis, is traditionally discarded but holds significant potential for resource recovery within a circular economy framework.
Faissal Tarrass, Meryem Benjelloun
doaj +3 more sources
Frontiers in Veterinary ScienceThe aim of this study is twofold: to characterize the epidemiology of idiopathic epilepsy (IE) in a large US primary care provider, and to investigate primary care veterinarians’ anti-seizure drugs (ASDs) prescribing practices.
Elisa Pompermaier +3 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The potential of forward osmosis in reducing water consumption in hemodialysis
Nefrología (English Edition)Hemodialysis is a life-sustaining treatment for patients with end-stage renal disease, but it is notoriously resource-intensive, requiring vast quantities of high-purity water.
Faissal Tarrass, Meryem Benjelloun
doaj +3 more sources