Results 91 to 100 of about 970,728 (295)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Toxicity Assessment of Long-Term Exposure to Hemodialysis Devices
Turkish Journal of NephrologyHemodialysis is a life-sustaining therapy for end-stage kidney disease, yet the devices enabling it paradoxically expose patients to chemical toxicants.
Faissal Tarrass, Meryem Benjelloun
doaj +1 more source
Mariner IV Mission to Mars. Part I [PDF]
, 1965 This technical report is a series of individual papers documenting the Mariner-Mars project from its beginning in 1962 following the successful Mariner-Venus mission. Part I is pre-encounter data.
James, Jack N.
core +1 more source
, 2007 We present the first calculation of saltation transport and dune formation on Mars and compare it to real dunes. We find that the rate at which grains are entrained into saltation on Mars is one order of magnitude higher than on Earth.
B. White +11 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
From molecules to minds – an integrative framework for living in space
Frontiers in Space TechnologiesAs humanity transitions from episodic exploration to sustained habitation beyond low Earth orbit, the long-term viability of human life in space has become a critical scientific challenge.
Susan Ip-Jewell +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
International Journal of Qualitative Studies on Health & Well-BeingPurpose This paper aims to extend and enrich the concept of self-care, through demonstrating how self-care can manifest as both a relational and multispecies endeavour.
Renelle McGlacken, Vanessa Ashall
doaj +1 more source