Results 51 to 60 of about 6,099 (263)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sintering of ceramics for clay in situ resource utilization on Mars

Open Ceramics, 2020
The sintering of wet processed Mars global simulant green bodies is explored. Green bodies shaped using slip casting, throwing on a potter’s wheel and additive manufacturing, including material extrusion (robocasting) and layerwise slurry deposition (LSD)
David Karl, Franz Kamutzki, Pedro Lima, Albert Gili, Thomas Duminy, Andrea Zocca, Jens Günster, Aleksander Gurlo   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Atmosphere of Mars

The Astrophysical Journal, 1926
Martian atmosphere examined through its redness, its albedo and its surface markings, noting also the composition of its two layers of particulate ...
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Earth – Mars Similarity Criteria for Martian Vehicles [PDF]

INCAS Bulletin, 2010
In order to select the most efficient kind of a martian exploring vehicle, the similarity criteria are deduced from the equilibrium movement in the terrestrial and martian conditions.
Octavian TRIFU, George SAVU
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research on the Detection Method of Martian Atmospheric Temperature and Pressure Profile Based on Laser Occultation Technology

Remote Sensing
As an important target of space exploration, Mars has attracted a lot of attention due to its unique geographical and atmospheric conditions. The detection of the vertical profiles of Mars atmospheric parameters provides deeper insights into the ...
Ye Liu, Wei Kong, Xue Shen, Tao Chen, Genghua Huang   +4 more
doaj   +1 more source

The Mars system revealed by the Martian Moons eXploration mission

Earth, Planets and Space, 2022
Japan Aerospace Exploration Agency (JAXA) plans a Phobos sample return mission (MMX: Martian Moons eXploration). In this study, we review the related works on the past climate of Mars, its evolution, and the present climate and weather to describe the ...
Kazunori Ogohara, Hiromu Nakagawa, Shohei Aoki, Toru Kouyama, Tomohiro Usui, Naoki Terada, Takeshi Imamura, Franck Montmessin, David Brain, Alain Doressoundiram, Thomas Gautier, Takuya Hara, Yuki Harada, Hitoshi Ikeda, Mizuho Koike, François Leblanc, Ramses Ramirez, Eric Sawyer, Kanako Seki, Aymeric Spiga, Ann Carine Vandaele, Shoichiro Yokota, Antonella Barucci, Shingo Kameda   +23 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source