Results 51 to 60 of about 113,191 (310)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mars and a Lunar Atmosphere [PDF]

Nature, 1912
IN NATURE, February 22, p. 565, reference is made to an interesting observation by Prof. Luther, of the Dusseldorf Observatory. The note states that he saw the half of the disc of Mars nearest the moon become green just before occultation on December 4, 1911, and he suggests that this may have been due to a lunar atmosphere. The time was 16h.
openaire   +4 more sources

Research on the Detection Method of Martian Atmospheric Temperature and Pressure Profile Based on Laser Occultation Technology

Remote Sensing
As an important target of space exploration, Mars has attracted a lot of attention due to its unique geographical and atmospheric conditions. The detection of the vertical profiles of Mars atmospheric parameters provides deeper insights into the ...
Ye Liu, Wei Kong, Xue Shen, Tao Chen, Genghua Huang   +4 more
doaj   +1 more source

Unique, non‐Earthlike, meteoritic ion behavior in upper atmosphere of Mars

Geophysical Research Letters, 2017
Interplanetary dust particles have long been expected to produce permanent ionospheric metal ion layers at Mars, as on Earth, but the two environments are so different that uncertainty existed as to whether terrestrial‐established understanding would ...
J. M. Grebowsky, M. Benna, J. M. C. Plane, G. A. Collinson, P. R. Mahaffy, B. M. Jakosky   +5 more
doaj   +1 more source

The Mars system revealed by the Martian Moons eXploration mission

Earth, Planets and Space, 2022
Japan Aerospace Exploration Agency (JAXA) plans a Phobos sample return mission (MMX: Martian Moons eXploration). In this study, we review the related works on the past climate of Mars, its evolution, and the present climate and weather to describe the ...
Kazunori Ogohara, Hiromu Nakagawa, Shohei Aoki, Toru Kouyama, Tomohiro Usui, Naoki Terada, Takeshi Imamura, Franck Montmessin, David Brain, Alain Doressoundiram, Thomas Gautier, Takuya Hara, Yuki Harada, Hitoshi Ikeda, Mizuho Koike, François Leblanc, Ramses Ramirez, Eric Sawyer, Kanako Seki, Aymeric Spiga, Ann Carine Vandaele, Shoichiro Yokota, Antonella Barucci, Shingo Kameda   +23 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The present and past climates of planet Mars

EPJ Web of Conferences, 2009
Mars is a small planet with a thin atmosphere of almost pure carbon dioxide. To first order, the Martian meteorology can be compared with what one would expect on a cold, dry desert-like Earth.
Forget F.
doaj   +1 more source

Trace gas assimilation of Mars orbiter observations [PDF]

, 2012
Ozone, water vapour and argon are minor constituents in the Martian atmosphere, observations of which can be of use in constraining atmospheric dynamical and physical processes.
Holmes, J. A., Lewis, S. R., Patel, M. R.   +2 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source