Results 121 to 130 of about 1,439,039 (347)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Distributed Cognition and the Experience of Presence in the Mars Exploration Rover Mission. [PDF]
Front Psychol, 2021 Chiappe D, Vervaeke J.
europepmc +1 more source
Proceedings of the 2nd Annual Conference on NASA/University Advanced Space Design Program [PDF]
Topics discussed include: lunar transportation system, Mars rover, lunar fiberglass production, geosynchronous space stations, regenerative system for growing plants, lunar mining devices, lunar oxygen transporation system, mobile remote manipulator ...
core +1 more source
Astrobiology and the Human Exploration of Mars [PDF]
, 2010 In March 2007, the Mars Exploration Program Analysis Group (MEPAG) chartered the Human Exploration of Mars Science Analysis Group (HEM-SAG), co-chaired by J. B. Garvin and J. S. Levine and consisting of about 30 Mars scientists from the U.S.
Beaty, David +3 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Acoustic monitoring of laser-induced phase transitions in minerals: implication for Mars exploration with SuperCam. [PDF]
Sci Rep, 2021 Chide B +7 more
europepmc +1 more source
Mini-rovers for Mars explorations [PDF]
Rovers are desirable for surface exploration because they allow sampling, and sample returns from several diverse locations on a planet's surface. Unfortunately, the rovers currently being examined for Mars exploration have several undesirable features ...
Miller, David P.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Trade studies for nuclear space power systems [PDF]
As human visions of space applications expand and as we probe further out into the universe, our needs for power will also expand, and missions will evolve which are enabled by nuclear power.
Bents, David J. +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source