Results 121 to 130 of about 140,234 (311)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Challenges of Mars Exploration
, 2019 The quest for Mars exploration stands as a testament to humanity's enduring interest and ambition to traverse new frontiers. Mars, the fourth planet from the Sun, gives a fascinating yet formidable target for exploration and capacity colonization.
Girdhari Jangid, Mini Sengar
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Seismic exploration for water on Mars [PDF]
It is proposed to soft-land three seismometers in the Utopia-Elysium region and three or more radio controlled explosive charges at nearby sites that can be accurately located by an orbiter.
Page, Thornton
core +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
The concept of the Mars airplane was developed as a potential vehicle for unmanned Mars exploration. It is suggested that its most appropriate use would be as an unmanned adjunct to a manned mission.
French, J. R.
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Aerospace systems and mission analysis research - Solar electric space mission analysis Final report [PDF]
Mission analysis for solar electric propelled spacecraft on Mars Orbiter, Jupiter flyby, and asteroid belt exploration ...
Handelsman, M. +2 more
core +1 more source
Mars Science Helicopter Conceptual Design [PDF]
, 2020 Robotic planetary aerial vehicles increase the range of terrain that can be examined, compared to traditional landers and rovers, and have more near-surface capability than orbiters. Aerial mobility is a promising possibility for planetary exploration as
Balaram, Jayarao +15 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source