Results 141 to 150 of about 1,439,039 (347)
ChallengesMars is a focus of New Space Age exploration and colonisation, but there are significant challenges to successful colonisation by humankind.
Daniel Keaney, Brigid Lucey, Karen Finn
doaj +1 more source
Seismic exploration for water on Mars [PDF]
It is proposed to soft-land three seismometers in the Utopia-Elysium region and three or more radio controlled explosive charges at nearby sites that can be accurately located by an orbiter.
Page, Thornton
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
MRSR: Rationale for a Mars Rover/Sample Return mission [PDF]
The Solar System Exploration Committee of the NASA Advisory Council has recommended that a Mars Rover/Sample Return mission be launched before the year 2000. The recommendation is consistent with the science objectives as outlined by the National Academy
Carr, Michael H.
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Aerospace systems and mission analysis research - Solar electric space mission analysis Final report [PDF]
Mission analysis for solar electric propelled spacecraft on Mars Orbiter, Jupiter flyby, and asteroid belt exploration ...
Handelsman, M. +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MarsBots: Robotic Learning Module [PDF]
, 2006 This learning module offers hands-on, minds-on activities investigating the Martian environment and robotic technologies of space exploration. The learning module contains 16 national standards-based lessons designed to progress logically from learning ...
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Potential Advantages of Conducting Short Duration Visits to the Martian Surface [PDF]
Recent NASA concepts for human missions to Mars, including the Evolvable Mars Campaign and Design Reference Architecture 5.0, have focused on the conduct of missions with long duration stays on the Martian surface.
Cirillo, William M. +4 more
core +1 more source