Results 181 to 190 of about 1,439,039 (347)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Recent Efforts Enabling Martian Rotorcraft Missions [PDF]

The Mars Helicopter (MH), launching as a part of the Mars 2020 mission, will begin a new era of planetary exploration. Mars research has historically been conducted through landers, rovers, and satellites.
Johnson, Wayne R., Koning, Witold, Kuang, Winnie, Withrow-Maser, Shannah   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Draft Genome Sequences of Bacillus glennii V44-8, Bacillus saganii V47-23a, Bacillus sp. Strain V59.32b, Bacillus sp. Strain MER_TA_151, and Paenibacillus sp. Strain MER_111, Isolated from Cleanrooms Where the Viking and Mars Exploration Rover Spacecraft Were Assembled. [PDF]

Microbiol Resour Announc, 2020
Becket E, Johnson KO, Burke CJ, Clark JJ, Cohen MJS, Coil DA, Eggleston CA, Farmer TL, Farr TR, Hernandez SM, Jaureguy JP, Jospin G, Khan A, Lee MD, McKee LN, O'Brien EM, Read BA, Saisho R, Seuylemezian A, Serrato-Arroyo SS, Steinecke D, Vaishampayan P.   +21 more
europepmc   +1 more source

Using XRD to Characterize Sediment Sorting in a Mars Analog Glacio-Fluvio-Eolian Basaltic Sedimentary System in Iceland [PDF]

The martian surface has a primarily basaltic composition and is dominated by sedimentary deposits. Ancient layered sedimentary rocks have been identified across the planet from orbit, have been studied in situ by the Mars Exploration Rovers and the Mars ...
Bedford, C. C., Champion, E., Ewing, R. C., Gray, P., Horgan, B., Lapotre, M. G. A., Mason, K., Nachon, M., Rampe, E. B., Reid, E., Sinha, P., Soto, A., Thorpe, M. T.   +12 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Planetary science questions for the manned exploration of Mars [PDF]

A major goal of a manned Mars mission is to explore the planet and to investigate scientific questions for which the intensive study of Mars is essential. The systematic exploration of planets was outlined by the National Academy of Science.
Blanchard, Douglas P.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Scientific questions for the exploration of the terrestrial planets and Jupiter - Advanced planetary missions technology program Progress report [PDF]

Scientific questions and experimental design for planetary exploration of Jupiter, Mars, Mercury, and ...
Adams, J. B., Fanale, F. P., Farmer, C. B., Gray, L. D., Mackin, R. J., Jr., Mc Donald, W. S., Miner, E. D., Newburn, R. L., Soffen, G. A.   +8 more
core   +1 more source