Results 141 to 150 of about 154,266 (330)

A Permanent Human Lunar Surface Presence Enabled by a CLV Class JUMP Lander [PDF]

There are compelling advantages of a human presence on the surface of the Moon, as evidenced partly by the preponderance of lunar surface architectures that have existed throughout NASA, industry, and academia since the Apollo program.
Howard, Robert L., Jr.
core   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Nuclear Electric Propulsion Technology Panel findings and recommendations [PDF]

Summarized are the findings and recommendations of a triagency (NASA/DOE/DOD) panel on Nuclear Electric Propulsion (NEP) Technology. NEP has been identified as a candidate nuclear propulsion technology for exploration of the Moon and Mars as part of the ...
Doherty, Michael P.
core   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Tribology of ZrC Coatings and Spherical Tips Acquired with Extraordinarily Stiff, Metal Atomic Force Microscopy Probes

Advanced Engineering Materials, EarlyView.
In this research, ZrC coatings are evaluated against various counterprobes at the microscale using novel super‐stiff atomic force microscopy cantilevers. The chemical composition of the coating is shown to be an important factor influencing coating hardness and Young's modulus, while surface roughness, counterprobe hardness, and surface energy are the ...
Piotr Jenczyk, Marcin Michałowski, Bogdan Warcholiński, Michał Milczarek, Adam Gilewicz   +4 more
wiley   +1 more source

Detection of visible-wavelength aurora on Mars. [PDF]

Sci Adv
Knutsen EW, McConnochie TH, Lemmon M, Donaldson C, Francis R, Legett C, Viet SB, Soret L, Toledo D, Apéstigue V, Witasse O, Montmessin F, Jolitz R, Schneider NM, Tamppari L, Cousin A, Wiens RC, Maurice S, Bell JF, Forni O, Lasue J, Pilleri P, Bertrand T, Patel P, Schröder S, Curry S, Lee CO, Rahmati A.   +27 more
europepmc   +1 more source

13kW Advanced Electric Propulsion Flight System Development and Qualification [PDF]

The next phase of robotic and human deep space exploration missions requires high performance, high power solar electric propulsion systems for large-scale science missions and cargo transportation.
Barber, Matthew, Cassady, Joseph, Jackson, Jerry, Miller, Scott, Peterson, Peter Y., Soendker, Erich, Welander, Ben   +6 more
core   +1 more source

Graphene–Catechol Dental Sealant: Antibacterial and Mechanical Evaluation

Advanced Engineering Materials, EarlyView.
This study presents dental sealants made with graphene and L‐DOPA‐modified graphene. L‐DOPA enhances graphene dispersion, improving sealant properties. The material shows antibacterial activity against S. mutans and L. casei, along with high strength and elasticity.
Renata Pereira, Flávio H. B. Aguiar, Rodrigo B. E. Lins, Maria C. A. J. Mainairdi, Bruna G. Silva, Marcela A. Ferretti, Klaus Rischka   +6 more
wiley   +1 more source

Critical investments in bioregenerative life support systems for bioastronautics and sustainable lunar exploration. [PDF]

NPJ Microgravity
Marshall Porterfield D, Tulodziecki D, Wheeler R, Davis Cross MK, Monje O, Rothschild LJ, Barker RJ, Schwertz H, Collicott S, Dutta S.   +9 more
europepmc   +1 more source