Results 201 to 210 of about 639,433 (345)

Mars Sample Return: From collection to curation of samples from a habitable world. [PDF]

Proc Natl Acad Sci U S A
McCubbin FM, Farley KA, Harrington AD, Hutzler A, Smith CL.   +4 more
europepmc   +1 more source

FXa‐Responsive Hydrogels to Craft Corneal Endothelial Lamellae

Advanced Healthcare Materials, EarlyView.
This study introduces a sacrificial, multicomponent biohybrid hydrogel system enabling stable scaffold‐free tissue engineering. Its efficacy is demonstrated through the ex vivo development, detachment, and transplantation of human corneal endothelial lamellae, achieving clinically relevant sizes for Descemet Membrane Endothelial Keratoplasty.
Mikhail V. Tsurkan, Juliane Bessert, Rabea Selzer, Sarah D. Tsurkan, Dagmar Pette, Manfred F. Maitz, Petra B. Welzel, Carsten Werner   +7 more
wiley   +1 more source

The elusive nature of Martian liquid brines. [PDF]

Proc Natl Acad Sci U S A
Chevrier VF, Slank RA.
europepmc   +1 more source

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization

Advanced Healthcare Materials, EarlyView.
The ability of human induced pluripotent stem cells (hiPSCs) to model developmental processes makes them a promising source for engineering testicular tissues to study in vitro maturation and sperm production. This work describes the first hiPSC‐derived testicular model and shows that it captures functional aspects of prepubertal testicular tissues ...
Meghan A Robinson, Sonia HY Kung, Khaled YM Youssef, Kali M Scheck, Robert H Bell, Funda Sar, Anne M Haegert, M Mahdi Asmae, Changfeng Cheng, Salina V Yeack, Bhairvi T Mathur, Feng Jiang, Colin C Collins, Faraz Hach, Stephanie M Willerth, Ryan K Flannigan   +15 more
wiley   +1 more source

The utility of animal models to inform the next generation of human space exploration. [PDF]

NPJ Microgravity
Duporge I, Pereira T, de Obeso SC, Ross JGB, J Lee S, G Hindle A.   +5 more
europepmc   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, EarlyView.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Advancing space medicine: a global perspective on in-orbit research and future directions. [PDF]

Mil Med Res
Chen SG, Chen XP, Wu B.
europepmc   +1 more source

Supercritical Fluid‐Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment

Advanced Healthcare Materials, EarlyView.
These findings advance tissue repair by offering a multifunctional filler that improves large‐scale volume retention, elasticity, and support for vascularized tissue growth. The decellularized extracellular matrix (dECM)‐based material provides low injection force and minimizes swelling, ensuring sustained volume. Combining CMC with supercritical fluid‐
Seol‐Ha Jeong, Jae Jun Kang, Ki‐Myo Kim, Mi hyun lee, Misun Cha, Su Hee Kim, Ji‐Ung Park   +6 more
wiley   +1 more source

Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel. [PDF]

Sci Rep
Okamura Y, Gochi K, Ishikawa T, Hayashi T, Fuseya S, Suzuki R, Kanai M, Inoue Y, Murakami Y, Sadaki S, Jeon H, Hayama M, Ishii H, Tsunakawa Y, Ochi H, Sato S, Hamada M, Abe C, Morita H, Okada R, Shiba D, Muratani M, Shinohara M, Akiyama T, Kudo T, Takahashi S.   +25 more
europepmc   +1 more source

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells

Advanced Healthcare Materials, EarlyView.
This study presents a custom‐made soft pneumatic device (SPD) that mimics complex mechanical forces and fluid flow to enhance in vitro cell differentiation. It shows that low mechanotransduction promotes MSC differentiation into osteoprogenitor cells, while high mechanotransduction causes structural disruptions and cell detachment, providing new ...
Gwang‐Bum Im, Jae Gyeong Lee, Hosub Lim, Jae‐Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak‐Rin Kim, Jeong Jae Wie, Suk Ho Bhang   +9 more
wiley   +1 more source