Results 61 to 70 of about 5,169 (289)
Continuity and Change in U.S. Space Exploration Approaches (2017–2025)
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политикаIn recent years, amid the increasing polarization in American society, the United States has witnessed growing divergences between its key parties on virtually all domestic and foreign policy issues. However, this trend has barely affected U.S.
P. G. Koshkin
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Mars Exploration Program and Mars Technology Program
, 2002 The Mars Exploration Program and constituent Mars Technology Program are described. Current, ongoing and future NASA-led missions are presented, including discussions of scientific accomplishments and objectives as well as technology validations ...
Whetsel, Charles W.
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 1993 An overview of the Mars Exploration Program is presented in outline and graphic form. Mission objectives, mission strategy, operations concept, transportation element, launch vehicle considerations and program schedule are ...
Weary, Dwayne
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mars Exploration Program 2007-08 Science Planning, with MEP Requests of MEPAG
, 2007 This slide presentation reviews the planning for the Mars Exploration Program. This includes information on the Mars Science Orbiter, the 2016-2018 planning teams, and updates to the Mars Exploration Analysis ...
Meyer, Michael, Beaty, David
core
Dynamic Modeling of Crew Performance for Long-Duration Space Missions
, 2005 Crew time is one of the most valuable and limited resources during long-duration space missions. Crew time requirements fluctuate depending on variations in crew performance.
Both, A. J. +7 more
core +2 more sources