Results 121 to 130 of about 360,067 (302)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Stealing a car to be a man : the importance of cars and driving in the gender identity of adolescent males [PDF]

open access: yes, 2005
Nationally vehicle theft is associated with approximately 40 fatalities per year with an estimated annual cost of one billion dollars. During 2000 - 2001 almost 139,000 motor vehicles (cars, motor cycles, campervans, and trucks) were stolen across ...
Williams, Clive Kenneth
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Tough, sensitive and sincere: how adolescent boys manage masculinities and emotions

open access: yesInternational Journal of Adolescence and Youth, 2016
This study aimed to explore adolescent boys’ views of masculinity and emotion management and their potential effects on well-being. Interviews with 33 adolescent boys aged 16–17 years in Sweden were analysed using grounded theory.
Eva Randell   +4 more
doaj   +1 more source

Australian Legends: historical explorations of Australian masculinity and film 1970-1995. [PDF]

open access: yes, 2010
The twin purpose of this research is to explore films as historically specific cultural texts, rather than representations of one historical moment, and to engage with historiographical debates surrounding representations of masculinity in Australian ...
Hanley, Galina
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Die Darstelung der Männlichkeit im Roman "Verführungen" (1996) von Marlene Streeruwitz

open access: yesBrünner Beiträge zur Germanistik und Nordistik, 2014
The paper deals with an interpretation of the masculinity in the novel Verführungen, written by Marlene Streeruwitz (∗1950), an Austrian author with a strong feminist position. The hegemonic masculinity represents the most dominant form of masculinity in
Dagmar Vincze
doaj  

The representation of Arab masculinity in advertising

open access: yesالباحث الإعلامي
The aim of this study is to utilize Semiotic analysis to analyze the representation of Gulf men in advertising a Kuwaiti brand. Based on two YouTube commercials as a case study, this article asks, How is Arab masculinity represented in advertising?
Abdullah Kassem Abdullah, Noha Mellor
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

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