Results 101 to 110 of about 113,885 (294)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Masculinity threat's role in rape blame

, 2016
The purpose of this study was to investigate how masculinity threat may enhance negative perceptions of rape victims (victim blame and token resistance) and also how masculinity contingency may play a role in these perceptions as well.
Eagan, Sarah Rose
core  

Brand and masculinity archetypes as an innovative research approach for analyzing consumer preferences on masculinity in advertising

Journal of Open Innovation: Technology, Market and Complexity
The research aims to explore consumer perceptions of masculinity in advertising in an innovative approach. The authors aimed to determine which type of masculinity and which brand and masculinity archetypes consumers favor in a masculine character.
Toms Kreicbergs, Deniss Ščeulovs, Artūrs Bernovskis   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Introduction : Mapping the field of masculinity studies

, 2020
During the last decades, masculinity studies has become a well-established part of interdisciplinary gender research. This introduction discusses three different narratives about the field: one that emphasizes its roots in social sciences, one that ...
Shefer, Tamara, Gottzén, Lucas,, Mellström, Ulf,   +2 more
core  

The Impact of Toxic Masculinity On Men's Mental Health [PDF]

, 2020
T SOC 165 Introduction To Sociology: Developing The Sociological ImaginationMy project is about how toxic masculinity can affect men's mental health.
Grewal, Amardeep
core  

LANGUAGE EXPRESSIONS IN CONSTRUCTING PHYSICAL MASCULINITY IN INDONESIAN TEEN LIT

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya, 2020
LANGUAGE EXPRESSIONS IN CONSTRUCTING PHYSICAL MASCULINITY IN INDONESIAN TEEN LIT Abstract: Teen lit serves a central position in the conception of masculinity in teenagers due to its closeness to them as readers.
Azizatuz Zahro, Anang Santoso, Dawud Dawud   +2 more
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source