Results 101 to 110 of about 360,067 (302)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Den orättvisaste orättvisan. Heroism och alternativ maskulinitet i Hans Erik Engqvists ungdomsroman Tredagarskriget

Barnboken: Tidskrift för Barnlitteraturforskning, 2014
”Wicked Wrongfulness. Heroism and Alternative Versions of Masculinity in Hans Erik Engqvist’s Young Adult Novel Three Days War”. This article examines the re-evaluation of modern masculinity in the YA novel Three Days War by the Swedish author Hans Erik ...
Olle Widhe
doaj   +1 more source

Magazine and reader constructions of 'metrosexuality' and masculinity: a membership categorisation analysis [PDF]

, 2011
Since the launch of men's lifestyle magazines in the 1980s, academic literature has predominantly focused on them as a cultural phenomenon arising from entrepreneurial and commercial initiatives and/or as cultural texts that proffer representations of ...
Baker C.D., Ballaster R., Beck U., Benwell B., Berger J., Beynon J., Brendan Gough, Chapman R., Coad D., Connell R.W., Edwards T., Edwards T., Edwards T., Featherstone M., Gill R., Hall M., Hermes J., Hester S., Jackson P., Jayyusi L., Jefferson G., Matthew Hall, McRobbie A., McRobbie A., Moore S., Morley D., Osgerby B., Sacks H., Simpson M., Stevenson N., Taylor Y., Vallis R., Wheaton B., Whitehead S.M.   +33 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Learning masculinities in a Japanese high school rugby club [PDF]

This paper draws on research conducted on a Tokyo high school rugby club to explore diversity in the masculinities formed through membership in the club.
Bourdieu P., Bourdieu P., Bourdieu P., Bourdieu P., Connell R. W., Connell R. W., Connell R. W., Glaser B., Gramsci A., Greenwood J., Kirk D., Kirk D., Laberge S., Lave J., Light R., Light R., Light R., Light R., McNay I., Merleau-Ponty M., Messner M., Messner M., Messner M., Mills M., Moeran B., Nakane C., Richard Light, Rohlen T., Sugimoto Y., Tomsen S., Welton D.   +30 more
core   +1 more source

Masculinity, Scatology, Mooning and the Queer/able Art of Gilbert & George: On the Visual Discourse of Male Ejaculation and Anal Penetration [PDF]

, 2011
The aim of this essay is to investigate the intersections between masculinity, shame, art, anality, the abject and embodiment by focusing on a particular period of the British art duo Gilbert & George's work in the 1990s.
CAKIRLAR, C
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Body Talk: Male Athletes Reflect on Sport, Injury, and Pain [PDF]

, 1994
This paper examines how participation in physically demanding sport, with its potential and actual injurious outcomes, both challenges and reinforces dominant notions of masculinity. Data from 16 in-depth interviews with former and current Canadian adult
McTeer, William, White, Philip, Young, Kevin   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source