Results 61 to 70 of about 20,980 (267)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Masculinity studies

, 2018
Der Artikel bietet einen konzisen und umfassenden Überblick über die historische Entwicklung und den aktuellen Stand der Masculinity Studies. Er geht dabei sowohl auf internationale als auch spezifisch deutsche Begebenheiten ein, bspw. bei der Institutionalisierung der Männlichkeitsforschung, diskutiert kritisch die Inflation des Krisenbegriffs in ...
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Den orättvisaste orättvisan. Heroism och alternativ maskulinitet i Hans Erik Engqvists ungdomsroman Tredagarskriget

Barnboken: Tidskrift för Barnlitteraturforskning, 2014
”Wicked Wrongfulness. Heroism and Alternative Versions of Masculinity in Hans Erik Engqvist’s Young Adult Novel Three Days War”. This article examines the re-evaluation of modern masculinity in the YA novel Three Days War by the Swedish author Hans Erik ...
Olle Widhe
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

L'Éternel Masculin

, 2003
Tout comme le féminin, le masculin peut s'envisager comme le résultat d'une construction historique et culturelle, envisagée ici à partir des divers champs des sciences humaines. Distinct du neutre et de l'universel (homo et vir ne sont pas le même homme), face au continent noir du féminin, il a aussi son histoire et ses énigmes.
Tain, Laurence, Mercader, Patricia
openaire   +2 more sources

Troublesome Masculinities: Masculinity in Trouble [PDF]

IDS Bulletin, 2009
This article explores the notion of troublesome' masculinities that characterise much of the policy discourse and programme thinking on problems of young men and gender. It critiques the dimorphism that shapes this view of young men's gender trouble, and the ‘culturalism’ that constrains the perception of the troubled times in which many young men live.
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Relationships between Grey Matter Volume in the Bilateral Superior Frontal Gyrus and Reactive Aggression Varied by Level of Traditional Masculinity

Brain Sciences
Although previous behavioral studies have associated reactive aggression (RA) and proactive aggression (PA) with traditional masculinity, further investigation is needed into the traditional masculinity-linked neuroanatomical characteristics of RA and PA.
Weijun Liu, Cody Ding, Ziang Li, Hong Chen   +3 more
doaj   +1 more source

Stars of the masculinity and Masculinity of the stars

Taḥqīqāt-i Farhangī-i Īrān, 2011
Change in social relations may challenge superiority of men over women; so men will need an ideology that reestablishes their superiority whenever such “crisis tendencies” happen. This ideology recommends an “Ideal Masculinity” and reestablishes “normal” pattern of manhood.
Hasan Chavoshian, Seyed Javad Hosseini Rasht Abadi   +1 more
openaire   +1 more source