Results 51 to 60 of about 10,693 (212)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Antivirus and antibacterial filters for face masks based on silver quantum dots [PDF]

Vojnosanitetski Pregled
Background/Aim. Available face masks, used to protect the respiratory system from various types of pathogens, show unsatisfactory efficiency because the size of viruses like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is much smaller ...
Jokanović Vukoman, Zdravković Nemanja, Petrović Božana, Živković Marija, Biočanin Vladimir, Aleksić Ema, Milutinović Jovana, Petrović Tamaš   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The influence of wearing masks and gloves due to COVID-19 pandemic on skin problems and skin care in students of Medical University in Lublin

Journal of Education, Health and Sport, 2020
Introduction. Our everyday life has changed drastically in these few months. The arrival of the new 2019-nCoV virus in December 2019 and its rapid spread from the city of Wuhan, China, has highlighted the increase in personal protective equipment (PPE ...
Aleksandra Jaremek, Wiktoria Chodun, Justyna Piechnik, Barbara Nieradko-Iwanicka   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

To mask or not to mask

Current trends in Internal Medicine, 2022
Schlegtendal, Anne (Dr. med.), Eitner, Lynn Bernadette (Dr. med.), Falkenstein, Michael (Prof. em. Dr. med. Dipl.-Psych. Dipl.-Ing.), Hoffmann, Anna Sophie (Dr. med.), Lücke, Thomas (Prof. Dr. med.), Sinningen, Kathrin (Dr. throph.), Brinkmann, Folke (Prof. Dr. med.)   +6 more
  +5 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Promoting the rational use of masks in community, home, and hospital settings in COVID-19 pandemic

MRIMS Journal of Health Sciences, 2020
The coronavirus disease-2019 (COVID-19) pandemic has been reported across 216 nations and territories since its emergence in the Wuhan city of China.
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava   +1 more
doaj   +1 more source