Results 81 to 90 of about 646,914 (294)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Learning Segmentation Masks with the Independence Prior

, 2018
An instance with a bad mask might make a composite image that uses it look fake. This encourages us to learn segmentation by generating realistic composite images.
Chen, Yimin, Dai, Songmin, Li, Xiaoqiang, Tong, Weiqin, Wang, Lu, Wu, Pin   +5 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Methods for Rapidly Processing Angular Masks of Next-Generation Galaxy Surveys

, 2008
As galaxy surveys become larger and more complex, keeping track of the completeness, magnitude limit, and other survey parameters as a function of direction on the sky becomes an increasingly challenging computational task.
Adelman-McCarthy, Andrew J. S. Hamilton, Banerji, Blanton, Bond, Calabretta, Colless, Collister, Conroy, da Costa, de Berg, Dor, Dor, Giannantonio, Glazebrook, Goodman, Grski, Grski, Hamilton, Hamilton, Hamilton, Hikage, Hivon, Huchra, J. Colin Hill, Kaiser, LSST Collaboration, M. E. C. Swanson, Maddox, Maddox, Maddox, Mandelbaum, Max Tegmark, Myers, Nishimichi, Oyaizu, Padmanabhan, Park, Park, Percival, Rassat, Reid, Saunders, Schlegel, Shen, Spergel, Stoughton, Strauss, Stubbs, Swanson, Szapudi, Tegmark, Tegmark, Tegmark, Tyson, Tyson, Wandelt, Wang, Yamamoto, York   +59 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Factors influencing mask use and physical distancing for COVID-19: A qualitative evidence synthesis

Journal of Public Health in Africa
Background: The World Health Organization (WHO) recommends a bundle of precautions to reduce community transmission of COVID-19, including mask use and physical distancing.
Dachi I. Arikpo, Okwu A. Onyema, Afiong O. Oku, Chibueze Meremikwu, Hannah Hamilton-Hurwitz, João P. Toledo, Kathleen Dunn, April Baller, Helen J. Smith, Martin M. Meremikwu   +9 more
doaj   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Health and care workers’ perceptions of PPE and physical distancing for COVID-19: A qualitative evidence synthesis

Journal of Public Health in Africa
Background: Despite the effectiveness of personal protective equipment (PPE) and physical distancing interventions for COVID-19 infection prevention and control (IPC), low uptake among health and care workers persists.
Dachi I. Arikpo, Afiong O. Oku, Okwu A. Onyema, Edward O. Odey, Hannah H. Hurwitz, João P. Toledo, Kathleen Dunn, April Baller, Helen J. Smith, Martin M. Meremikwu   +9 more
doaj   +1 more source

Masked balls

Cambridge Opera Journal, 2002
In the course of his insightful analysis of Act II of Un ballo in maschera, Harold Powers recurs to two critics of earlier generations who hyperbolically describe how, to cite his more measured summary, ‘the drama has turned into music as the opera was being composed.
openaire   +2 more sources