Results 191 to 200 of about 17,128 (260)

Microbial exposure and host responses to infection reshape the disease trajectory of MASLD. [PDF]

Front Cell Infect Microbiol
Zhang Y, Xun Q, Liu S, Zhuang B, Zang M, Tan C, Cui Y, Li R, Zhang Q.   +8 more
europepmc   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source

Role of glucagon in metabolic diseases

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Currently, diabetes is defined as “a chronic hyperglycemic state resulting from the absolute or relative insufficiency of insulin action,” emphasizing its characterization as an insulin‐related disease. However, glucagon dysregulation should also play a critical role in the pathophysiology of type 2 diabetes.
Tadahiro Kitamura, Yoko Tabei, Masaki Kobayashi   +2 more
wiley   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective. [PDF]

Liver Int
Cazzaniga A, Frigo S, Cherubini A, Rrapaj E, Valenti L.   +4 more
europepmc   +1 more source

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Zachary Bloomgarden
wiley   +1 more source

AI-driven diagnostic and prognostic models for metabolic dysfunction-associated steatotic liver disease: insights from clinical, imaging, and multi-omics studies-a scoping review. [PDF]

Front Med (Lausanne)
Sujana M, Vivekananda GN.
europepmc   +1 more source

Hepatic steatosis risk in nonobese Chinese adults with type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) may be an important comorbidity in nonobese Chinese adults with type 1 diabetes (T1D). We assessed the likelihood of hepatic steatosis using the hepatic steatosis index (HSI) in 47 nonobese Chinese adults with T1D (mean age 46.9 ± 14.1 years; BMI 22.6 ± 2.5 kg/m2) and examined ...
Zehua Jin, Jianhua Ma, Yuanyang Zhao, Yi Luo, Christopher K Rayner, Tongzhi Wu, Yong Luo   +6 more
wiley   +1 more source

Betaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury. [PDF]

Mol Biomed
Chang MH, Lee CH, Cho Y, Son RG, Lee S, Park S, Kim J, Koh YH, Cho AE, Pack SP, Seo M, Lee JH, Cha H.   +12 more
europepmc   +1 more source

Psychosocial aspects and mental health burden of pediatric MASLD. [PDF]

Front Endocrinol (Lausanne)
Ganakumar V, Mahaling A, Goroshi M, Ghatnatti V.   +3 more
europepmc   +1 more source