Results 61 to 70 of about 231,447 (261)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

High-resolution distributed vertical strain and velocity from repeat borehole logging by optical televiewer: Derwael Ice Rise, Antarctica

Journal of Glaciology, 2020
Direct measurements of spatially distributed vertical strain within ice masses are scientifically valuable but challenging to acquire. We use manual marker tracking and automatic cross correlation between two repeat optical televiewer (OPTV) images of an
Bryn Hubbard, Morgane Philippe, Frank Pattyn, Reinhard Drews, Tun Jan Young, Carine Bruyninx, Nicolas Bergeot, Karen Fjøsne, Jean-Louis Tison   +8 more
doaj   +1 more source

Reconstruction of mass balance and firn stratigraphy during the 1996–2011 warm period at high altitude on Mount Ortles, Eastern Alps: a comparison of modelled and ice core results

The Cryosphere
. Paleoclimatic glacial archives in low-latitude mountain regions are increasingly affected by melt, which leads to heavy percolation and can remove snow and firn accumulated across months, seasons, or even years.
L. Carturan, A. Ihle, F. Cazorzi, Tiziana Lazzarina Zendrini, Fabrizio De Blasi, G. Dalla Fontana, G. Dreossi, D. Festi, Bryan Mark, K. Oeggl, R. Seppi, B. Stenni, Paolo Gabrielli   +12 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Using structure from motion photogrammetry to measure past glacier changes from historic aerial photographs

Journal of Glaciology, 2017
Quantifying historic changes in glacier size and mass balance is important for understanding how the cryosphere responds to climate variability and change.
LAUREN J. VARGO, BRIAN M. ANDERSON, HUW J. HORGAN, ANDREW N. MACKINTOSH, ANDREW M. LORREY, MERIJN THORNTON   +5 more
doaj   +1 more source

Mass balance of the Sary-Tor Glacier reproduced from meteorological data

Лëд и снег, 2021
Mass balance bn is the most important indicator of a glacier evolution. However, after the decay of the USSR direct measurements of bn performed in 1985–1989 in the Inner Tien Shan, including the Sary-Tor Glacier in Ak-Shiyrak Massif, had been desisted ...
V. V. Popovnin, A. S. Gubanov, R. A. Satylkanov, B. O. Ermenbayev   +3 more
doaj   +1 more source

Glacier mass balance reconstruction by sublimation induced enrichment of chemical species on Cerro Tapado (Chilean Andes)

, 2005
. A 36 m long ice core down to bedrock from the Cerro Tapado glacier (5536 m a.s.l, 30°08' S, 69°55' W) was analyzed to reconstruct past climatic conditions for Northern Chile.
P. Ginot, C. Kull, U. Schotterer, M. Schwikowski, H. Gäggeler   +4 more
semanticscholar   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source