Results 131 to 140 of about 5,188,005 (243)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Using mass-balance principles to optimize nutrition of lettuce. [PDF]

Front Plant Sci
Langenfeld NJ, Bugbee B.
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Mass balance of the Greenland and Antarctic ice sheets from the 1970s to 2023. [PDF]

Sci Data
Otosaka IN, Shepherd A, Amory C, Horwath M, Ivins ER, King MD, Nowicki S, Payne AJ, Rignot E, Sørensen LS, Schlegel NJ, Simon KM, Smith BE, Sutterley TC, van den Broeke MR, Velicogna I, A G, Agosta C, Ditmar P, Döhne T, Engdahl ME, Fettweis X, Forsberg R, Gardner AS, Gilbert L, Goelzer H, Gourmelen N, Groh A, Hansen N, Harig C, Helm V, Khan SA, Kittel C, Langen PL, Larsen M, Loomis BD, McMillan M, Medley B, Melini D, Mottram RH, Muir A, Nilsson J, Noël B, Pattle ME, Roca I Aparici M, Sasgen I, Save HV, Scheuchl B, Schrama EJO, Schröder L, Seo KW, Simonsen SB, Slater T, Spada G, Vishwakarma BD, Wever N, Wiese DN, Wouters B.   +57 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Design characteristics of mass balance studies conducted for protein kinase inhibitors. [PDF]

Cancer Chemother Pharmacol
Riechelman B, Bolks R, Oude Munnink TH, Swen JJ, Jansman FGA, Klont F.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Pharmacokinetics, mass balance, and metabolism of [¹⁴C]SPH3127 (sitokiren), a novel direct renin inhibitor in humans. [PDF]

Front Pharmacol
Ma S, Huang X, Yan S, Liu H, Zhang H, Zhang Y, Cui W, Ding C, Diao X, Miao L.   +9 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Human Radiolabeled Mass Balance Studies Supporting New Drugs Approved by FDA Between 2019 and 2023. [PDF]

Clin Transl Sci
Ramamoorthy A, Chen A, Chow ECY, Guinn D, Iyer A, Pahwa S, Ren Y, Shukla C, Doddapaneni S, Danielsen ZY.   +9 more
europepmc   +1 more source