Results 41 to 50 of about 12,157 (211)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Sustainable Recovery of Phlorotannins from Durvillaea incurvata: Integrated Extraction and Purification with Advanced Characterization

Antioxidants
The rising demand for bioactive compounds from marine resources highlights the need for sustainable separation technologies. This study introduces an integrated process combining ultrasound-assisted extraction (USAE) and resin purification (RP) to ...
Pamela Raquel Rivera-Tovar, Gabriela Contreras-Contreras, Paulina Isabel Rivas-Reyes, Jara Pérez-Jiménez, Maximiliano Martínez-Cifuentes, José Ricardo Pérez-Correa, María Salomé Mariotti-Celis   +6 more
doaj   +1 more source

Modeling Accumulated Volume of Landslides Using Remote Sensing and DTM Data

Remote Sensing, 2014
Landslides, like other natural hazards, such as avalanches, floods, and debris flows, may result in a lot of property damage and human casualties. The volume of landslide deposits is a key parameter for landslide studies and disaster relief. Using remote
Zhengchao Chen, Bing Zhang, Yongshun Han, Zhengli Zuo, Xiaoyong Zhang   +4 more
doaj   +1 more source

Mass Balance of the Antarctic Ice Sheet in the Early 21st Century

Remote Sensing, 2023
Mass loss from the Antarctic Ice Sheet (AIS) is an important contributor to global sea level rise. To examine the recent ice loss, we estimated the mass budget of the AIS from 2000 to 2020 using multiple ice velocity datasets, state-of-the-art ice ...
Tian Yang, Qi Liang, Lei Zheng, Teng Li, Zhuoqi Chen, Fengming Hui, Xiao Cheng   +6 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Petrologic History of Lunar Phosphates Accounts for the Water Content of the Moon’s Mare Basalts

Geosciences, 2019
We present reaction balancing and thermodynamic modeling based on microtextural observations and mineral chemistry, to constrain the history of phosphate crystallization within two lunar mare basalts, 10003 and 14053.
Antonio M. Álvarez-Valero, John F. Pernet-Fisher, Leo M. Kriegsman   +2 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Regional glacier melt modeling: insights from surface energy balance and positive degree-day comparisons

Journal of Glaciology
Large-scale glacier mass-balance models often rely on positive degree-day (PDD) melt models, which have known limitations. This study evaluates a relatively simple, elevation-dependent surface energy balance (SEB) model that requires minimal downscaling ...
Hannah Phelps, Valentina Radić, Scott N Williamson   +2 more
doaj   +1 more source