Results 51 to 60 of about 12,157 (211)

Downscaling of the global climate model data for the mass balance calculation of mountain glaciers

open access: yesЛëд и снег, 2017
In this paper, we consider a hybrid method of downscaling of the GCM‑generated meteorological fields to the characteristic spatial resolution which is usually used for modeling of a single mountain glacier mass balance.
P. A. Morozova, O. O. Rybak
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Spatio-temporal changes of glaciers, geomorphology, and meteorological influences on debris flow in the alpine environment: insights from a case study in the Hopar Nagar Valley, Northern Pakistan

open access: yesGeomatics, Natural Hazards & Risk
Alpine environments are becoming increasingly vulnerable to climate change, as retreating glaciers and abrupt weather shifts lead to frequent flooding and debris flows globally.
Abrar Hussain   +4 more
doaj   +1 more source

Modeling of biobasins of an oil refinery wastewater treatment plant [PDF]

open access: yesJournal of BioScience and Biotechnology, 2015
The biobasins of the largest wastewater treatment plant (WWTP) on the Balkans has been examined. Samples were taken four times from the inlet and outlet flow. The concentration of the total hydrocarbons, benzene, toluene, ethylbenzene, p-xylene, m-xylene,
RADOSTIN K. KUTSAROV, IVAN S. CHOBANOV
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Determination of mass balances and ionic balances in animal manure.

open access: yesNetherlands Journal of Agricultural Science, 1990
Liquid and solid fractions of three different pig slurry samples and a poultry manure sample were isolated through high speed centrifugation followed by ultrafiltration. The gross ionic composition of the liquid manure fractions could be described by: K+, Na+, Ca2+, Mg2+, Cl-, bicarbonate, weakly acidic cations (ammonium) and weakly alkaline anions ...
Japenga, J., Harmsen, K.
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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