Results 51 to 60 of about 696,538 (259)

Regional glacier melt modeling: insights from surface energy balance and positive degree-day comparisons

Journal of Glaciology
Large-scale glacier mass-balance models often rely on positive degree-day (PDD) melt models, which have known limitations. This study evaluates a relatively simple, elevation-dependent surface energy balance (SEB) model that requires minimal downscaling ...
Hannah Phelps, Valentina Radić, Scott N Williamson   +2 more
doaj   +1 more source

Downscaling of the global climate model data for the mass balance calculation of mountain glaciers

Лëд и снег, 2017
In this paper, we consider a hybrid method of downscaling of the GCM‑generated meteorological fields to the characteristic spatial resolution which is usually used for modeling of a single mountain glacier mass balance.
P. A. Morozova, O. O. Rybak
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Spatio-temporal changes of glaciers, geomorphology, and meteorological influences on debris flow in the alpine environment: insights from a case study in the Hopar Nagar Valley, Northern Pakistan

Geomatics, Natural Hazards & Risk
Alpine environments are becoming increasingly vulnerable to climate change, as retreating glaciers and abrupt weather shifts lead to frequent flooding and debris flows globally.
Abrar Hussain, Jingfeng Liu, Muzaffar Ali, Wajid Hassan, Chengyuan Wang   +4 more
doaj   +1 more source

Modeling of biobasins of an oil refinery wastewater treatment plant [PDF]

Journal of BioScience and Biotechnology, 2015
The biobasins of the largest wastewater treatment plant (WWTP) on the Balkans has been examined. Samples were taken four times from the inlet and outlet flow. The concentration of the total hydrocarbons, benzene, toluene, ethylbenzene, p-xylene, m-xylene,
RADOSTIN K. KUTSAROV, IVAN S. CHOBANOV
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mass-balance parameters derived from a synthetic network of mass-balance glaciers [PDF]

Journal of Glaciology, 2012
AbstractGlacier mass-balance parameters such as the equilibrium-line altitude (ELA) play an important role when working with large glacier samples. While the number of observational mass-balance series to derive such parameters is limited, more and more modeled data are becoming available.Here we explore the possibilities of analyzing such 'synthetic ...
Machguth, H., W. Haeberli, and F. Paul
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source