Results 71 to 80 of about 5,188,005 (243)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Characteristics of the Vernagtferner mass balance for the period from 1964 to 2014
, 2015 The main characteristics of the Vernagtferner mass balance are sumarized in the table below. The mass balance years from 1964/65 to 2003/2004 are listed.
Ludwig N Braun (6971093) +5 more
core +1 more source
, 2022 CRREL-type IMB ZS2010 is an autonomous instrument that was installed on the landfast sea ice in Prydz Bay, east Antarctica in July 2010. The buoy was deployed at 69.35°S; 76.42°E, ~3 km from the coast of Station Zhongshan with initial thicknesses of snow
Li, Bingrui, Li, Na, Lei, Ruibo
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
, 2021 Sugar Balance is an exclusive herbal supplement that manages you to stay healthy by controlling your blood glucose level with the aid of clinically proven herbal extracts from plants to stay healthy and fit ever.
Sugar Balance
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Enhanced estimation of glacier mass balance in unsampled areas by means of topographic data
, 2008 A new method was developed to estimate the mass balance in unsampled areas from existing datasets. Three years of mass-balance data from two glaciers in the central Italian Alps were used to develop and test a multiple-regression method based exclusively
CAZORZI, Federico +6 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source